CAS 72324-18-6|Stepronin

Introduction：Basic information about CAS 72324-18-6|Stepronin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Stepronin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Stepronin
CAS Number	72324-18-6	Molecular Weight	273.32900
Density	1.428 g/cm3	Boiling Point	521.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₁NO₄S₂	Melting Point	168-170ºC
MSDS	/	Flash Point	269ºC

Names

Name	2-[2-(thiophene-2-carbonylsulfanyl)propanoylamino]acetic acid
Synonym	More Synonyms

Stepronin BiologicalActivity

Description	Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands[1].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>Others >>Others
In Vitro	Stepronin (0.1-100 µM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium[1]. Stepronin (10-100 µM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium[1]. Stepronin (100 µM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands[1]. Cell Viability Assay[1] Cell Line: Canine tracheal epithelium (from adult and 10 to 25 kg-weight mongrel dogs of both sexes) Concentration: 0.1-100 µM; 10-100 µM Incubation Time: 20 min (pre-treat) Result: Significantly inhibited ISOP-induced SCC and PD values, as well as basal secretion. Cell Viability Assay[1] Cell Line: Submucosal glands (from adult and 10 to 25 kg-weight mongrel dogs of both sexes) Concentration: 100 µM Incubation Time: 20 min (pre-treat) Result: Significantly inhibited ISOP- induced [3H]-glycoconjugate secretion.

Chemical & Physical Properties

Density	1.428 g/cm3
Boiling Point	521.2ºC at 760 mmHg
Melting Point	168-170ºC
Molecular Formula	C₁₀H₁₁NO₄S₂
Molecular Weight	273.32900
Flash Point	269ºC
Exact Mass	273.01300
PSA	137.01000
LogP	1.60170
Index of Refraction	1.609
InChIKey	JNYSEDHQJCOWQU-UHFFFAOYSA-N
SMILES	CC(SC(=O)c1cccs1)C(=O)NCC(=O)O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0813680

CHEMICAL NAME :: Glycine, N-(1-oxo-2-((2-thienylcarbonyl)thio)propyl)-

CAS REGISTRY NUMBER :: 72324-18-6

LAST UPDATED :: 199201

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H11-N-O4-S2

MOLECULAR WEIGHT :: 273.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4242354

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1801 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4242354

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3336 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1511 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4242354

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1584 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 534 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984

Synonyms

Stepronine

Steproninum

Prostenoglycine

Bronco-plus

MFCD00867405

EINECS 276-587-4

Stepronin

Tiofacic

Tiase

Stepronino

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