CAS 198470-85-8|Parecoxib sodiuM
Introduction：Basic information about CAS 198470-85-8|Parecoxib sodiuM, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Parecoxib sodiuM | ||
|---|---|---|---|
| CAS Number | 198470-85-8 | Molecular Weight | 392.404 |
| Density | / | Boiling Point | 538ºC at 760mmHg |
| Molecular Formula | C19H17N2NaO4S | Melting Point | 273-275°C |
| MSDS | / | Flash Point | 279.2ºC |
Names
| Name | Parecoxib sodium |
|---|---|
| Synonym | More Synonyms |
Parecoxib sodiuM BiologicalActivity
| Description | Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/Immunology |
| Target | COX-2 |
| References | [1]. Schreder H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13. [2]. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012 Feb;37(2):321-9. [3]. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp Ther Med. 2013 Jul;6(1):275-279. |
Chemical & Physical Properties
| Boiling Point | 538ºC at 760mmHg |
|---|---|
| Melting Point | 273-275°C |
| Molecular Formula | C19H17N2NaO4S |
| Molecular Weight | 392.404 |
| Flash Point | 279.2ºC |
| Exact Mass | 392.080658 |
| PSA | 85.62000 |
| LogP | 5.39680 |
| InChIKey | HQPVVKXJNZEAFW-UHFFFAOYSA-M |
| SMILES | CCC(=O)[N-]S(=O)(=O)c1ccc(-c2c(-c3ccccc3)noc2C)cc1.[Na+] |
| Storage condition | Refrigerator |
Synonyms
| Rayzon |
| Parecoxib sodiuM salt |
| Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (1:1) |
| N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt |
| Sodium {[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}(propionyl)azanide |
| N-[[p-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propionamide Sodium Salt |
| Parecoxib (Sodium) |
