Introduction：Basic information about CAS 6287-90-7|Br-C10-methyl ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432). PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein[1].
Related Catalog
Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target
Alkyl/ether
References
[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911.
Chemical & Physical Properties
Density
1.157 g/mL at 25ºC(lit.)
Boiling Point
115ºC0.04 mm Hg(lit.)
Melting Point
13°C(lit.)
Molecular Formula
C12H23BrO2
Molecular Weight
279.21400
Flash Point
>230 °F
Exact Mass
278.08800
PSA
26.30000
LogP
4.06520
Index of Refraction
n20/D 1.465(lit.)
InChIKey
HFNPVFKUZYCDIB-UHFFFAOYSA-N
SMILES
COC(=O)CCCCCCCCCCBr
Safety Information
Personal Protective Equipment
Eyeshields;Gloves
RIDADR
NONH for all modes of transport
HS Code
2915900090
Customs
HS Code
2915900090
Summary
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%
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