Introduction：Basic information about CAS 106083-71-0|Radafaxine (hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Radafaxine (hydrochloride) |
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| CAS Number | 106083-71-0 | Molecular Weight | 292.20100 |
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| Density | 1.144g/cm3 | Boiling Point | 386.6ºC at 760mmHg |
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| Molecular Formula | C13H19Cl2NO2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 187.6ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | (2S,3S)-Hydroxybupropion hydrochloride |
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| Synonym | More Synonyms |
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Radafaxine (hydrochloride) BiologicalActivity
| Description | Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Monoamine TransporterResearch Areas >>Neurological Disease |
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| References | [1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70. [2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93. |
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Chemical & Physical Properties
| Density | 1.144g/cm3 |
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| Boiling Point | 386.6ºC at 760mmHg |
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| Molecular Formula | C13H19Cl2NO2 |
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| Molecular Weight | 292.20100 |
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| Flash Point | 187.6ºC |
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| Exact Mass | 291.07900 |
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| PSA | 41.49000 |
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| LogP | 3.40280 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.523 |
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| Storage condition | 2-8℃ |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H319 |
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| Precautionary Statements | P305 + P351 + P338 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride |
| Radafaxine (hydrochloride) |
