Introduction：Basic information about CAS 24677-86-9|Lenperone Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lenperone Hydrochloride |
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| CAS Number | 24677-86-9 | Molecular Weight | 407.88100 |
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| Density | 1.186g/cm3 | Boiling Point | 507.9ºC at 760mmHg |
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| Molecular Formula | C22H24ClF2NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 261ºC |
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Names
| Name | Lenperone hydrochloride |
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| Synonym | More Synonyms |
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Lenperone Hydrochloride BiologicalActivity
| Description | Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| In Vivo | Lenperone hydrochloride (0.16 和 0.44 mg/kg；肌内注射；一次) 降低健康犬的平均值胃食管括约肌压力 (GESP)[1]。 Lenperone hydrochloride (0.5，1.0 和 2.0 mg/kg；皮下注射) 在脑损伤大鼠中显示抗精神疾病的作用，诱导剂量依赖的镇静状态并减少双侧间质核、终纹[2]。 Animal Model: Healthy adult dogs[1] Dosage: 0.16 and 0.44 mg/kg Administration: Intramuscular injection; 0.16 and 0.44 mg/kg, once Result: Effectively decreased gastroesophageal sphincter pressure (GESP) of dogs. |
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| References | [1]. Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. [2]. Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58. |
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Chemical & Physical Properties
| Density | 1.186g/cm3 |
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| Boiling Point | 507.9ºC at 760mmHg |
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| Molecular Formula | C22H24ClF2NO2 |
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| Molecular Weight | 407.88100 |
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| Flash Point | 261ºC |
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| Exact Mass | 407.14600 |
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| PSA | 37.38000 |
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| LogP | 5.26250 |
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| InChIKey | BUPKTBMYUMORNV-UHFFFAOYSA-N |
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| SMILES | Cl.O=C(CCCN1CCC(C(=O)c2ccc(F)cc2)CC1)c1ccc(F)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EU2456000
- CHEMICAL NAME :
- Butyrophenone, 4-(4-(p-fluorobenzoyl)piperidino)-4'-fluoro-, hydrochloride
- CAS REGISTRY NUMBER :
- 24677-86-9
- LAST UPDATED :
- 198812
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H23-F2-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 407.92
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970
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Synonyms
