Introduction：Basic information about CAS 1072145-33-5|ERRα antagonist-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ERRα antagonist-1 |
|---|
| CAS Number | 1072145-33-5 | Molecular Weight | 377.52600 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C21H19N3S2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | N-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-imine |
|---|
| Synonym | More Synonyms |
|---|
ERRα antagonist-1 BiologicalActivity
| Description | ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1]. |
|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer |
|---|
| Target | ERRα |
|---|
| References | [1]. Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related |
|---|
Chemical & Physical Properties
| Molecular Formula | C21H19N3S2 |
|---|
| Molecular Weight | 377.52600 |
|---|
| Exact Mass | 377.10200 |
|---|
| PSA | 78.56000 |
|---|
| LogP | 4.14090 |
|---|
| InChIKey | OWLQZFQCFCNPKV-UHFFFAOYSA-N |
|---|
| SMILES | C1=Cc2ccccc2C(N=C2SCCN2C2=NCCS2)c2ccccc21 |
|---|
Synonyms
| N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine |
