CAS 17692-31-8|Dropropizine
Introduction：Basic information about CAS 17692-31-8|Dropropizine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dropropizine | ||
|---|---|---|---|
| CAS Number | 17692-31-8 | Molecular Weight | 236.310 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 412.7±34.0 °C at 760 mmHg |
| Molecular Formula | C13H20N2O2 | Melting Point | 105-108ºC |
| MSDS | ChineseUSA | Flash Point | 220.9±24.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3-(4-phenylpiperazin-1-yl)propane-1,2-diol |
|---|---|
| Synonym | More Synonyms |
Dropropizine BiologicalActivity
| Description | Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 412.7±34.0 °C at 760 mmHg |
| Melting Point | 105-108ºC |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.310 |
| Flash Point | 220.9±24.3 °C |
| Exact Mass | 236.152481 |
| PSA | 46.94000 |
| LogP | 0.46 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.577 |
| InChIKey | PTVWPYVOOKLBCG-UHFFFAOYSA-N |
| SMILES | OCC(O)CN1CCN(c2ccccc2)CC1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TZ1074800 |
| HS Code | 2933599090 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles25
More Articles| Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough. J. Int. Med. Res. 23(3) , 175-83, (1995) The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e... | |
| Efficacy of levodropropizine in pediatric cough. Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012) Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir... | |
| Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry. Ther. Drug Monit. 26(4) , 441-9, (2004) Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma... |
Synonyms
| Dropropizine |
| 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)- |
| Tussilex |
| 1-(2,3-Dihydroxypropyl)-4-phenylpiperazine |
| (+-)-Dropropizine |
| Ribex |
| EINECS 241-683-7 |
| Larylin |
| Ditustat |
| 1-Phenyl-4-(2,3-dihydroxypropyl)piperazine |
| 1-Phenyl-4-(2,3-dihydroxypropyl)diethylenediamine |
| Dipropizine |
| MFCD00079124 |
| 3-(4-phenylpiperazin-1-yl)propane-1,2-diol |
| Dopropizin |
| Catabex |
| levodropropizine |
| 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol |
| Katril |
