Introduction：Basic information about CAS 532-48-9|Euparin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Euparin |
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| CAS Number | 532-48-9 | Molecular Weight | 216.23300 |
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| Density | 1.187g/cm3 | Boiling Point | 258.3ºC at 760mmHg |
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| Molecular Formula | C13H12O3 | Melting Point | 152-153℃ |
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| MSDS | / | Flash Point | 110ºC |
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Names
| Name | 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone |
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| Synonym | More Synonyms |
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Euparin BiologicalActivity
| Description | Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Neurological Disease |
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| In Vitro | In Vero cells, Euparin shows antiviral activity against poliovirus types 1, 2, and 3 with EC50 values of 0.47 µg/mL, 0.12 µg/mL, and 0.15 µg/mL, respectively[1]. |
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| In Vivo | Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2]. |
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| References | [1]. aría Florencia Visintini Jaime, et al. Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med. 2013;2013:402364. [2]. Xu-Meng Han, et al. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500. |
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Chemical & Physical Properties
| Density | 1.187g/cm3 |
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| Boiling Point | 258.3ºC at 760mmHg |
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| Melting Point | 152-153℃ |
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| Molecular Formula | C13H12O3 |
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| Molecular Weight | 216.23300 |
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| Flash Point | 110ºC |
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| Exact Mass | 216.07900 |
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| PSA | 50.44000 |
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| LogP | 3.37410 |
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| Index of Refraction | 1.602 |
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| InChIKey | OPUFDNZTKHPZHM-UHFFFAOYSA-N |
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| SMILES | C=C(C)c1cc2cc(C(C)=O)c(O)cc2o1 |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2932999099 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-(6-Hydroxy-2-isopropenyl-benzofuran-5-yl)-aethanon |
| 5-acetyl-6-hydroxy-2-isopropenylbenzofuran |
| 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone |
| 1-[6-hydroxy-2-(1-methylethenyl)-5-benzofuranyl]-ethanone |
| Euparin |
| 1-(6-hydroxy-2-isopropenyl-benzofuran-5-yl)-ethanone |
