CAS 80665-72-1|Fuziline

Introduction:Basic information about CAS 80665-72-1|Fuziline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameFuziline
CAS Number80665-72-1Molecular Weight453.569
Density1.4±0.1 g/cm3Boiling Point596.9±50.0 °C at 760 mmHg
Molecular FormulaC24H39NO7Melting Point206-207ºC
MSDS/Flash Point314.8±30.1 °C

Names

Name15-α-hydroxyneoline
SynonymMore Synonyms

Fuziline BiologicalActivity

DescriptionFuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii[1].
Related CatalogSignaling Pathways >>Others >>Others
In VitroFuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability[1].
In VivoFuziline exhibits the mean half-life of 5.93 hours, 6.13 hours and 5.12 hours for 14 mg/kg, 2 4 mg/kg and 4 mg/kg, respectively, by oral administration in rat[2].
References

[1]. Xiong L, et al. Alkaloids isolated from the lateral root of Aconitum carmichaelii. Molecules. 2012 Aug 20;17(8):9939-46.

[2]. Li YX, et al. Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2014 Dec;28(12):1707-13.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point596.9±50.0 °C at 760 mmHg
Melting Point206-207ºC
Molecular FormulaC24H39NO7
Molecular Weight453.569
Flash Point314.8±30.1 °C
Exact Mass453.272644
PSA111.85000
LogP-1.32
Vapour Pressure0.0±3.8 mmHg at 25°C
Index of Refraction1.617
InChIKeyFPECZWKKKKZPPP-PVALPMDTSA-N
SMILESCCN1CC2(COC)CCC(O)C34C5CC6C(O)C5C(O)(C(O)C6OC)C(C(OC)C23)C14
Storage condition2-8C

Synonyms

(1α,6α,10α,13ξ,14α,15α,16β,17ξ)-20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14,15-tetrol
senbusine-C
Aconitane-1,8,14,15-tetrol,20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-,(1alpha,6alpha,14alpha,15alpha,16beta)
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1α,6α,10α,13ξ,14α,15α,16β,17ξ)-
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