CAS 76996-27-5|Garcinone C

Introduction：Basic information about CAS 76996-27-5|Garcinone C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGarcinone C
CAS Number76996-27-5Molecular Weight414.448
Density1.367Boiling Point689.0±55.0 °C at 760 mmHg
Molecular FormulaC23H26O7Melting Point/
MSDS/Flash Point239.7±25.0 °C

Names

Name1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)xanthen-9-one
SynonymMore Synonyms

Garcinone C BiologicalActivity

DescriptionGarcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia Champ that is used as an anti-inflammatory, analgesia, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner[1].
Related CatalogSignaling Pathways >>Stem Cell/Wnt >>STATResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>ATM/ATRSignaling Pathways >>JAK/STAT Signaling >>STATSignaling Pathways >>Cell Cycle/DNA Damage >>CDKSignaling Pathways >>PI3K/Akt/mTOR >>ATM/ATR
Target

ATR

Stat-3

CDK7

References

[1]. Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39(3):1485-1493.

Chemical & Physical Properties

Density1.367
Boiling Point689.0±55.0 °C at 760 mmHg
Molecular FormulaC23H26O7
Molecular Weight414.448
Flash Point239.7±25.0 °C
Exact Mass414.167847
PSA131.36000
LogP3.40
Vapour Pressure0.0±2.3 mmHg at 25°C
Index of Refraction1.656
InChIKeyHLOCLVMUASBDDP-UHFFFAOYSA-N
SMILESCC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CCC(C)(C)O)c3c(=O)c2c1O

Safety Information

Hazard CodesXi

Synonyms

1,3,6,7-Tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Garcinone C
9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methyl-2-buten-1-yl)-
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