Introduction：Basic information about CAS 2831-75-6|Daurinoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Daurinoline |
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| CAS Number | 2831-75-6 | Molecular Weight | 610.739 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 724.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C37H42N2O6 | Melting Point | 100-103ºC |
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| MSDS | / | Flash Point | 392.0±32.9 °C |
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Names
| Name | (1R)-1-[4-(5-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-i soquinolinyl]methyl}-2-hydroxyphenoxy)benzyl]-7-methoxy-2-methyl- 1,2,3,4-tetrahydro-6-isoquinolinol |
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| Synonym | More Synonyms |
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Daurinoline BiologicalActivity
| Description | Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Daurinoline inhibits the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells[1]. |
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| References | [1]. Dan-Dan Li, et al. Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol. Environ Toxicol Pharmacol. 2019 Feb;66:109-115. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 724.5±60.0 °C at 760 mmHg |
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| Melting Point | 100-103ºC |
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| Molecular Formula | C37H42N2O6 |
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| Molecular Weight | 610.739 |
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| Flash Point | 392.0±32.9 °C |
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| Exact Mass | 610.304260 |
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| PSA | 83.86000 |
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| LogP | 5.84 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.618 |
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| InChIKey | APIHNXDZCYDPTF-FIRIVFDPSA-N |
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| SMILES | COc1cc2c(cc1O)CCN(C)C2Cc1ccc(Oc2cc(CC3c4cc(OC)c(OC)cc4CCN3C)ccc2O)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 13-Ethyleneacetaldaunomycinone |
| (1R)-1-[4-(5-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-hydroxyphenoxy)benzyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol |
| (1R)-1-[4-(5-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-hydroxyphenoxy)benzyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydro-6-isoquinolinol |
| 5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-8-(2-methyl-1,3-dioxolan-2-yl)-,(8S-cis)-(9CI) |
| Daurinoline |
| Daunomycinone 13-ethylene ketal |
| 6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-[2-hydroxy-5-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-7-methoxy-2-methyl-, (1R)- |
