Introduction：Basic information about CAS 143313-51-3|Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid) |
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| CAS Number | 143313-51-3 | Molecular Weight | 492.522 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 937.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C23H32N4O8 | Melting Point | / |
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| MSDS | / | Flash Point | 520.9±34.3 °C |
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Names
| Name | ac-yvad-cho |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/Immunology |
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| Target | IL-1β:3 nM (Ki) IL-1β:0.76 nM (Ki) |
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| In Vitro | Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1]. |
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| In Vivo | Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1]. Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1]. Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1]. Animal Model: CD1 female mice Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly. Animal Model: CD1 female mice Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection. Animal Model: P. acnes-sensitized mice Dosage: 30 mg/kg Administration: I.p.; 6 hours Result: Suppressed IL-1β levels. |
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| References | [1]. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 937.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C23H32N4O8 |
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| Molecular Weight | 492.522 |
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| Flash Point | 520.9±34.3 °C |
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| Exact Mass | 492.222015 |
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| PSA | 191.00000 |
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| LogP | 0.79 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.552 |
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| Storage condition | −20°C |
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Safety Information
Synonyms
| pase inhibitor i |
| acetyl-yvad-aldehyde |
| ice inhibitor |
| ac-yvad-aldehyde |
| N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide |
| L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-((1S)-2-carboxy-1-formylethyl)- |
| tyr-val-ala-asp-cho |
| N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide |
| yvad-cho |
| L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]- |
| ice inhibitor i |
