CAS 6601-66-7|6-Demethoxytangeretin

Introduction：Basic information about CAS 6601-66-7|6-Demethoxytangeretin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 6-Demethoxytangeretin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	6-Demethoxytangeretin
CAS Number	6601-66-7	Molecular Weight	342.343
Density	1.243±0.06 g/cm3	Boiling Point	536.9±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₈O₆	Melting Point	216-217 ºC
MSDS	/	Flash Point	237.5±30.2 °C

Names

Name	5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
Synonym	More Synonyms

6-Demethoxytangeretin BiologicalActivity

Description	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].
Related Catalog	Research Areas >>CancerResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological DiseaseSignaling Pathways >>Epigenetics >>Epigenetic Reader Domain
References	[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Description

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].

Related Catalog

Research Areas >>CancerResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological DiseaseSignaling Pathways >>Epigenetics >>Epigenetic Reader Domain

References

[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5.

[2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Chemical & Physical Properties

Density	1.243±0.06 g/cm3
Boiling Point	536.9±50.0 °C at 760 mmHg
Melting Point	216-217 ºC
Molecular Formula	C₁₉H₁₈O₆
Molecular Weight	342.343
Flash Point	237.5±30.2 °C
Exact Mass	342.110352
PSA	67.13000
LogP	3.06
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.575
InChIKey	DDGJUTBQQURRGE-UHFFFAOYSA-N
SMILES	COc1ccc(-c2cc(=O)c3c(OC)cc(OC)c(OC)c3o2)cc1
Storage condition	2-8℃
Water Solubility	Practically insoluble (0.027 g/L) (25 ºC)

Safety Information

Hazard Codes	Xi
HS Code	2914509090

Customs

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Synonyms

6-Demethoxytangeretin

4',5,7,8-Tetramethoxyflavone

5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-(4-methoxyphenyl)-

5,7,8,4'-tetramethoxyflavone

UNII-2U2U884D0P

6-Demethoxytangeritin

Tetra-O-methylisoscutellarein

tetramethyl-o-isoscutellarein

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