Introduction：Basic information about CAS 28178-92-9|Futoquinol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Futoquinol |
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| CAS Number | 28178-92-9 | Molecular Weight | 354.396 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 515.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H22O5 | Melting Point | / |
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| MSDS | / | Flash Point | 225.5±30.2 °C |
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Names
| Name | 4-[(E)-1-(1,3-benzodioxol-5-yl)prop-1-en-2-yl]-4,5-dimethoxy-2-prop-2-enylcyclohexa-2,5-dien-1-one |
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| Synonym | More Synonyms |
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Futoquinol BiologicalActivity
| Description | Futoquinol is a neolignan isolated from the dried aerial parts of Piper kadsura (Piperaceae). Futoquinol potently inhibits NO production in microglia cells. Futoquinol has anti-neuroinflammatory activities[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| In Vitro | Futoquinol potently inhibits NO production with an IC50 value of 16.8 μM in LPS-activated BV-2 cells, a microglia cell line[1]. |
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| References | [1]. Ki Hyun Kim, et al. Neolignans from Piper kadsura and their anti-neuroinflammatory activity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):409-12. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 515.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H22O5 |
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| Molecular Weight | 354.396 |
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| Flash Point | 225.5±30.2 °C |
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| Exact Mass | 354.146729 |
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| PSA | 53.99000 |
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| LogP | 4.82 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.582 |
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| InChIKey | AOZTYYBGNNXAOI-NTEUORMPSA-N |
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| SMILES | C=CCC1=CC(OC)(C(C)=Cc2ccc3c(c2)OCO3)C(OC)=CC1=O |
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Safety Information
Synonyms
| 2-Allyl-4-[(1E)-1-(1,3-benzodioxol-5-yl)-1-propen-2-yl]-4,5-dimethoxy-2,5-cyclohexadien-1-one |
| 2-Allyl-4-[(E)-2-(1,3-benzodioxol-5-yl)-1-methylethenyl]-4,5-dimethoxy-2,5-cyclohexadien-1-one |
| (E)-2-Allyl-4-(2-(1,3-benzodioxol-5-yl)-1-methylvinyl)-4,5-dimethoxy-2,5-cyclohexadien-1-one |
| 2,5-Cyclohexadien-1-one, 4-[(E)-2-(1,3-benzodioxol-5-yl)-1-methylethenyl]-4,5-dimethoxy-2-(2-propen-1-yl)- |
| Futoquinol |
