Introduction：Basic information about CAS 17910-09-7|Curzerene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Curzerene |
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| CAS Number | 17910-09-7 | Molecular Weight | 216.319 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 282.8±40.0 °C at 760 mmHg |
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| Molecular Formula | C15H20O | Melting Point | / |
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| MSDS | / | Flash Point | 117.5±14.2 °C |
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Names
| Name | isofuranogermacrene |
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| Synonym | More Synonyms |
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Curzerene BiologicalActivity
| Description | Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Gutathione S-transferase |
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| Target | GSTA1[1] |
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| In Vitro | Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1]. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1]. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1]. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1]. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1]. Cell Viability Assay[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. Apoptosis Analysis[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced apoptosis of the cells in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced G2/M cell cycle arrest of SPC A1 cells. RT-PCR[1] Cell Line: SPC-A1 cells Concentration: 6.25 µM, 25 µM, 100 µM Incubation Time: 48 hours Result: Decreased GSTA1 mRNA expression. |
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| References | [1]. Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 282.8±40.0 °C at 760 mmHg |
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| Molecular Formula | C15H20O |
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| Molecular Weight | 216.319 |
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| Flash Point | 117.5±14.2 °C |
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| Exact Mass | 216.151413 |
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| PSA | 13.14000 |
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| LogP | 5.78 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.539 |
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| InChIKey | HICAMHOOTMOHPA-AWKYBWMHSA-N |
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| SMILES | C=CC1(C)Cc2occ(C)c2CC1C(=C)C |
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| Storage condition | 2-8℃ |
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Synonyms
| Benzofuran, 6-ethenyl-4,5,6,7-tetrahydro-3,6-dimethyl-5-(1-methylethenyl)-, (6S)- |
| (6S)-5-Isopropenyl-3,6-dimethyl-6-vinyl-4,5,6,7-tetrahydro-1-benzofuran |
| Curzerene |
