CAS 541-15-1|L-Carnitine inner salt
Introduction：Basic information about CAS 541-15-1|L-Carnitine inner salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Carnitine inner salt | ||
|---|---|---|---|
| CAS Number | 541-15-1 | Molecular Weight | 161.199 |
| Density | / | Boiling Point | / |
| Molecular Formula | C7H15NO3 | Melting Point | 197-212 °C(lit.) |
| MSDS | USA | Flash Point | / |
Names
| Name | (R)-carnitine |
|---|---|
| Synonym | More Synonyms |
L-Carnitine inner salt BiologicalActivity
| Description | L-carnitine is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.Target: OthersL-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine can also be found in many foods, but red meats, such as beef and lamb, are the best choices for adding carnitine into the diet [1]. Administering L-carnitine (510 mg/day) to patients with the disease. L-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. L-carnitine efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration [2]. L-carnitine and its derivatives show promise in the treatment of chronic conditions and diseases associated with mitochondrial dysfunction but further translational studies are needed to fully explore their potential [3]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Marcovina, S.M., et al., Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine. Transl Res, 2013. 161(2): p. 73-84. [2]. Pekala, J., et al., L-carnitine--metabolic functions and meaning in humans life. Curr Drug Metab, 2011. 12(7): p. 667-78. [3]. Miyagawa, T., et al., Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One, 2013. 8(1): p. e53707. |
Chemical & Physical Properties
| Melting Point | 197-212 °C(lit.) |
|---|---|
| Molecular Formula | C7H15NO3 |
| Molecular Weight | 161.199 |
| Exact Mass | 161.105194 |
| PSA | 60.36000 |
| LogP | -4.52 |
| Index of Refraction | -32 ° (C=1, H2O) |
| InChIKey | PHIQHXFUZVPYII-ZCFIWIBFSA-N |
| SMILES | C[N+](C)(C)CC(O)CC(=O)[O-] |
| Storage condition | 2-8°C |
| Water Solubility | 2500 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9 gm/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 35,645,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,558,1979
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | BP2980000 |
| HS Code | 29239000 |
Customs
| HS Code | 29239000 |
|---|
Articles155
More Articles| Metabolic and tissue-specific regulation of acyl-CoA metabolism. PLoS ONE 10(3) , e0116587, (2015) Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS). Conversely,... | |
| Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis. World J. Gastroenterol. 20(31) , 10876-85, (2014) To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model.Rats were divided into seven groups. Four groups received oral butyrate... | |
| Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. J. Nutr. 144(12) , 1977-84, (2014) Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa... |
Synonyms
| L-(-)-Carnitine |
| karnitin |
| ST 198 |
| EINECS 208-768-0 |
| 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Hydroxide Inner Salt |
| Carnitrine |
| USPorFCC |
| (R)-Carnitine |
| Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- |
| L-CARNITIN |
| 3-Hydroxy-4-(trimethylammonio)butanoate |
| g-Trimethylammonium-b-hydroxybutirate |
| CAR-OH |
| Vitamin BT |
| Monocamin |
| 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt |
| (-)-Carnitine |
| Carnitene |
| DL-Carnitine |
| (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate |
| carnitine (L-form) |
| (R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide inner salt |
| γ-Trimethyl-β-hydroxybutyrobetaine |
| Carnitine, (-)- |
| 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)- |
| (R)-3-hydroxy-4-(trimethylammonio)butanoate |
| (-)-L-Carnitin |
| L(-)-Carnitine |
| Carnitine, L- |
| 3-Hydroxy-4-trimethylammoniobutanoate |
| UNII:S7UI8SM58A |
| (L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide inner salt |
| Carnitine DL-form |
| L-Carnitine |
| BICARNESINE |
| Cardiogen |
| 4-Copab |
| L-Carnitine inner salt |
| g-Trimethyl-b-hydroxybutyrobetaine |
| (3R)-3-Hydroxy-4-(trimethylammonio)butanoate |
| Levocarnitine |
| g-Amino-b-hydroxybutyric Acid Trimethylbetaine |
| MFCD00038747 |
| (−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate |
| D,L-carnitine |
| (±)-carnitine |
| Carniking |
| carnitine |
| Carnitor |
