CAS 123171-59-5|Cefepime Dihydrochloride Monohydrate
Introduction：Basic information about CAS 123171-59-5|Cefepime Dihydrochloride Monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cefepime Dihydrochloride Monohydrate | ||
|---|---|---|---|
| CAS Number | 123171-59-5 | Molecular Weight | 571.498 |
| Density | / | Boiling Point | / |
| Molecular Formula | C19H28Cl2N6O6S2 | Melting Point | 150ºC(dec.) |
| MSDS | / | Flash Point | / |
Names
| Name | cefepime hydrochloride |
|---|---|
| Synonym | More Synonyms |
Cefepime Dihydrochloride Monohydrate BiologicalActivity
| Description | Cefepime Dihydrochloride Monohydrate is a broad-spectrum cephalosporin with enhanced coverage against Gram-positive and Gram-negative bacteria.Target: AntibacterialCefepime is an extended-spectrum parenteral cephalosporin antibiotic active in vitro against a broad spectrum of gram-positive and gram-negative aerobic bacteria. Cefepime dosing was 1-4 g/day (0.5-2.0 g twice daily) for adults; ceftazidime dosing was 1-6 g/day (0.5 g every 12 hours to 2.0 g every 8 hours). A limited number of cefepime-treated patients received 2 g every 8 hours. The median length of dosing for both cefepime and ceftazidime was 7 days [1]. Cefepime has a decreased propensity to induce beta-lactamases compared with other beta-lactam antibiotics. Cefepime has a pharmacokinetic disposition similar to that of other renally eliminated cephalosporins, with a half-life of approximately 2 hours. Cefepime has demonstrated clinical efficacy against a variety of infections, including urinary tract infections, pneumonia, and skin and skin structure infections. Cefepime is generally well tolerated [2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
| References | [1]. Neu, H.C., Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Am J Med, 1996. 100(6A): p. 68S-75S. [2]. Wynd, M.A. and J.A. Paladino, Cefepime: a fourth-generation parenteral cephalosporin. Ann Pharmacother, 1996. 30(12): p. 1414-24. |
Chemical & Physical Properties
| Melting Point | 150ºC(dec.) |
|---|---|
| Molecular Formula | C19H28Cl2N6O6S2 |
| Molecular Weight | 571.498 |
| Exact Mass | 570.088867 |
| PSA | 212.81000 |
| LogP | 1.12860 |
| InChIKey | LRAJHPGSGBRUJN-OMIVUECESA-N |
| SMILES | CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCCC3)CSC12)c1csc(N)n1.Cl.Cl.O |
| Storage condition | Store at 0-5°C |
Safety Information
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 29419000 |
Articles2
More Articles| A degradation study of cefepime hydrochloride in solutions under various stress conditions by TLC-densitometry. Biomed. Chromatogr. 29(3) , 388-95, (2015) A rapid, accurate and sensitive thin-layer chromatography (TLC) method with densitometric detection has been developed and validated for the determination of cefepime in pharmaceuticals. Chromatograph... | |
| In vitro and in vivo antibacterial activity of Pogostone. Chin. Med. J. 127(23) , 4001-5, (2014) Our pervious antibacterial studies on several traditional Chinese medicines have found that Patchouli oil from Pogostemon cablin had significant antibacterial activity against methicillin-resistant St... |
Synonyms
| cefepime dihydrochloride monohydrate |
| Cefepime hydrochloride |
| Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride, hydrochloride, hydrate (1:1:1:1) |
| MFCD06804606 |
| Axepim |
| 1-{[(6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidinium chloride hydrochloride hydrate (1:1:1:1) |
| pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt, hydrochloride, hydrate (1:2:1) |
| (6R-(6a,7b(Z)))-1-((7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidinium Chloride Monohydrochloride Monohydrate |
| 1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidinium Chloride 72-(Z)-(O-Methyloxime) Monohydrochloride Monohydrate |
| (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate dihydrochloride hydrate |
| Cefepime chloride hydrochloride hydrate |
| Cefepime (Dihydrochloride Monohydrate) |
