Introduction：Basic information about CAS 5250-39-5|Flucloxacillin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Flucloxacillin |
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| CAS Number | 5250-39-5 | Molecular Weight | 453.872 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 677.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H17ClFN3O5S | Melting Point | / |
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| MSDS | / | Flash Point | 363.4±31.5 °C |
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Names
| Name | flucloxacillin |
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| Synonym | More Synonyms |
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Flucloxacillin BiologicalActivity
| Description | Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vivo | Flucloxacillin (200 mg/kg; i.p.; three times/day, for 21 days; male Wistar rats) has effective against the most common bacterial strains in periprosthetic infection[1]. Animal Model: Male Wistar rats[1] Dosage: 200 mg/kg Administration: Intraperitoneal injection; three times/day, for 21 days Result: Reducted germs in the biofilm and in the bone tissue. |
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| References | [1]. Greimel F, et, al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017 Jun 14;11:1729-1736. [2]. Comber KR, Merrikin DJ, Sutherland R. Antibacterial activity and synergy, in vitro and in vivo, of a combination of amoxycillin and flucloxacillin. Chemotherapy. 1979;25(1):30-9. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 677.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H17ClFN3O5S |
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| Molecular Weight | 453.872 |
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| Flash Point | 363.4±31.5 °C |
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| Exact Mass | 453.056152 |
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| PSA | 138.04000 |
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| LogP | 2.60 |
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| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
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| Index of Refraction | 1.672 |
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| InChIKey | UIOFUWFRIANQPC-JKIFEVAISA-N |
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| SMILES | Cc1onc(-c2c(F)cccc2Cl)c1C(=O)NC1C(=O)N2C1SC(C)(C)C2C(=O)O |
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Synonyms
| Flucloxacillin |
| Floxapen |
| Culpen |
| (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Flopen |
| (2S,5R,6R)-6-({[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Abboflox |
| EINECS 226-051-0 |
| Flucil |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| Flupen |
| Ladropen |
| MFCD00864886 |
| Floxacillin |
| Staphcil |
| Staphylex |
| FK 900 |
| Penplus |
| Stafoxil |
| BRL 2039 |
