CAS 574-84-5|Fraxetin
| Common Name | Fraxetin | ||
|---|---|---|---|
| CAS Number | 574-84-5 | Molecular Weight | 208.167 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 472.0±45.0 °C at 760 mmHg |
| Molecular Formula | C10H8O5 | Melting Point | 230-232°C |
| MSDS | ChineseUSA | Flash Point | 196.0±22.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 7,8-dihydroxy-6-methoxychromen-2-one |
|---|---|
| Synonym | More Synonyms |
Fraxetin BiologicalActivity
| Description | Fraxetin is isolated from Cortex Fraxini. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Apoptosis |
| References | [1]. Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104. [2]. Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14(6):7374-7378. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 472.0±45.0 °C at 760 mmHg |
| Melting Point | 230-232°C |
| Molecular Formula | C10H8O5 |
| Molecular Weight | 208.167 |
| Flash Point | 196.0±22.2 °C |
| Exact Mass | 208.037170 |
| PSA | 79.90000 |
| LogP | 0.59 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.648 |
| InChIKey | HAVWRBANWNTOJX-UHFFFAOYSA-N |
| SMILES | COc1cc2ccc(=O)oc2c(O)c1O |
| Storage condition | 2~8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332-H315-H319-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2932209090 |
Customs
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles14
More Articles| [Studies on chemical constituents from stem barks of Fraxinus paxiana]. Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008) To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with... | |
| Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Biochimie 95(10) , 1848-54, (2013) Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihy... | |
| [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity]. Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008) To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech... |
Synonyms
| Coumarin, 7,8-dihydroxy-6-methoxy- |
| EINECS 209-376-2 |
| 6-methoxy-7,8-dihydroxycoumarin |
| 7,8-Dihydroxy-6-methoxy-2H-chromen-2-one |
| 2H-1-Benzopyran-2-one,7,8-dihydroxy-6-methoxy |
| 7,8-Dihydroxy-6-methoxycoumarin |
| 2H-1-Benzopyran-2-one, 7,8-dihydroxy-6-methoxy- |
| 7,8-dihydroxy-6-methoxy-benzopyran-2-one |
| 7,8-Dihydroxy-6-methoxy-2H-1-benzopyran-2-one |
| Fraxetin |
| MFCD00006873 |
