Introduction：Basic information about CAS 136085-37-5|Lobetyolin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lobetyolin |
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| CAS Number | 136085-37-5 | Molecular Weight | 396.431 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 698.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H28O8 | Melting Point | / |
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| MSDS | / | Flash Point | 376.2±31.5 °C |
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Names
| Name | Lobetyolin |
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| Synonym | More Synonyms |
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Lobetyolin BiologicalActivity
| Description | Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseaseNatural Products >>Others |
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| In Vitro | Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively[1]. |
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| Cell Assay | After 24 hours of serum deprivation, cells are pretreated with Lobetyolin, lobetyol or methyl linoleate (1, 10, and 100 µM), for 30 minutes and then treated with phorbol 12-myristate 13-acetate (PMA; 10 ng/mL) for 24 hours in serum-free RPMI 1640. After 24 hours, the spent media are collected to measure the secretion of MUC5AC protein and cells are lysed with buffer solution containing 20 mM Tris, 0.5% NP-40, 250 mM NaCl, 3 mM EDTA, 3 mM EGTA, and protease inhibitor cocktail and collected to measure the production of MUC5AC protein (in 24-well culture plate)[1]. |
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| References | [1]. Yoon YP, et al. Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells. Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 698.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H28O8 |
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| Molecular Weight | 396.431 |
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| Flash Point | 376.2±31.5 °C |
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| Exact Mass | 396.178406 |
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| PSA | 139.84000 |
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| LogP | 2.02 |
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| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
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| Index of Refraction | 1.607 |
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| InChIKey | MMMUDYVKKPDZHS-UPPVCQNNSA-N |
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| SMILES | CC=CC#CC#CC(O)C(C=CCCCO)OC1OC(CO)C(O)C(O)C1O |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | 24/25 |
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Synonyms
| (4E,12E)-1,7-Dihydroxy-4,12-tetradecadiene-8,10-diyn-6-yl β-D-glucopyranoside |
| (4E,12E)-1,7-Dihydroxytetradeca-4,12-diene-8,10-diyn-6-yl β-D-glucopyranoside |
| β-D-Glucopyranoside, (7E)-2-hydroxy-1-[(1E)-5-hydroxy-1-penten-1-yl]-7-nonene-3,5-diyn-1-yl |
| (2R,3R,4S,5S,6R)-2-[(4E,12E)-1,7-dihydroxytetradeca-4,12-dien-8,10-diyn-6-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol |
