CAS 24211-30-1|Farrerol

Introduction：Basic information about CAS 24211-30-1|Farrerol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Farrerol BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Farrerol
CAS Number	24211-30-1	Molecular Weight	300.306
Density	1.4±0.1 g/cm3	Boiling Point	583.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆O₅	Melting Point	/
MSDS	USA	Flash Point	219.7±23.6 °C

Names

Name	5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one
Synonym	More Synonyms

Farrerol BiologicalActivity

Description	Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects[1][2][3][4][5][6].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
In Vitro	Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation[1]. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line[2]. Farrerol inhibits angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway[3]. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition[4]. Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy[6].
In Vivo	Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways[5].
References	[1]. Ran X, et al. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. Int J Mol Sci. 2018 Jul 13;19(7). [2]. Cui B, et al. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Biomed Pharmacother. 2019 Jan;109:112-119. [3]. Dai F, et al. Farrerol inhibited angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. Phytomedicine. 2016 Jun 15;23(7):686-93. [4]. Li B, et al. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition. Microb Pathog. 2019 Jun;131:277. [5]. Li Y, et al. Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways. Int Immunopharmacol. 2019 Oct;75:105739. [6]. Wang L, et al. Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy. Int J Biol Sci. 2019 Jan 29;15(4):788-799.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	583.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆O₅
Molecular Weight	300.306
Flash Point	219.7±23.6 °C
Exact Mass	300.099762
PSA	86.99000
LogP	4.11
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.662
InChIKey	DYHOLQACRGJEHX-UHFFFAOYSA-N
SMILES	Cc1c(O)c(C)c2c(c1O)C(=O)CC(c1ccc(O)cc1)O2
Storage condition	2~8℃

Safety Information

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

EINECS 246-080-2

4',5,7-Trihydroxy-6,8-dimethylflavanone

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-

Farrerol

5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethylchroman-4-one

5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one

Farresol

Cyrtopterinetin

6,8-dimethyl-5,7,4'-trihydroxyflavanone

MFCD00017315

matteucinol

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