CAS 32619-42-4|Oleuropein
| Common Name | Oleuropein | ||
|---|---|---|---|
| CAS Number | 32619-42-4 | Molecular Weight | 540.514 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 772.9±60.0 °C at 760 mmHg |
| Molecular Formula | C25H32O13 | Melting Point | 89-90ºC |
| MSDS | ChineseUSA | Flash Point | 257.0±26.4 °C |
Names
| Name | Oleuropein |
|---|---|
| Synonym | More Synonyms |
Oleuropein BiologicalActivity
| Description | Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Others >>Aromatase |
| Target | PPARγ Apoptosis Aromatase |
| In Vitro | Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2]. |
| References | [1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376. [2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 772.9±60.0 °C at 760 mmHg |
| Melting Point | 89-90ºC |
| Molecular Formula | C25H32O13 |
| Molecular Weight | 540.514 |
| Flash Point | 257.0±26.4 °C |
| Exact Mass | 540.184265 |
| PSA | 201.67000 |
| LogP | -0.91 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.630 |
| InChIKey | RFWGABANNQMHMZ-DXNYSGJVSA-N |
| SMILES | CC=C1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CC(=O)OCCc1ccc(O)c(O)c1 |
| Storage condition | room temp |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2938909090 |
Customs
| HS Code | 2938909090 |
|---|
Articles32
More Articles| Rapid screening of oleuropein from olive leaves using matrix solid-phase dispersion and high-performance liquid chromatography. J. AOAC Int. 97(4) , 1109-13, (2014) Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with convention... | |
| A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS. J. Pharm. Biomed. Anal. 72 , 121-6, (2013) Olive leaves, an easily available natural low-cost material, constitute a source of extracts with significant antitumor activity that inhibits cell proliferation in several breast-cancer-cell models. ... | |
| Antiproliferative effect of oleuropein in prostate cell lines. Int. J. Oncol. 41(1) , 31-8, (2012) Currently, there is increasing interest in the in vivo protective effects of natural antioxidants found in dietary plants against oxidative damage caused by free radical species. Oxidative stress has ... |
Synonyms
| Olive Leaf Extract |
| MFCD00017493 |
| Oleuropein |
| oleuropein glucoside |
| EINECS 251-129-6 |
| Methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylate |
| 2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, (2S,3E,4S)- |
