Introduction：Basic information about CAS 892489-52-0|AZD 3988, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AZD 3988 |
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| CAS Number | 892489-52-0 | Molecular Weight | 456.44 |
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| Density | 1.402 | Boiling Point | / |
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| Molecular Formula | C23H22F2N4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid |
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| Synonym | More Synonyms |
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AZD 3988 BiologicalActivity
| Description | AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Acyltransferase |
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| Target | IC50: 6 nM (h DGAT-1), 5 nM (Rat DGAT-1), 11 nM (Mouse DGAT-1)[1] |
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| References | [1]. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8. |
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Chemical & Physical Properties
| Density | 1.402 |
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| Molecular Formula | C23H22F2N4O4 |
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| Molecular Weight | 456.44 |
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| Exact Mass | 456.16100 |
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| PSA | 117.35000 |
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| LogP | 5.23820 |
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| Index of Refraction | 1.627 |
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| InChIKey | NGEBYTLALFOQKI-UHFFFAOYSA-N |
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| SMILES | O=C(O)CC1CCC(c2ccc(NC(=O)c3nnc(Nc4ccc(F)c(F)c4)o3)cc2)CC1 |
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Synonyms
| 2H-Cyclopenta[b]furan-2-one,hexahydro-6-hydroxy |
| (trans-4-{4-[({5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetic acid |
| 6-Hydroxyhexahydrocyclopenta[b]furan-2-one |
| (trans-2,3-Dihydroxy-cyclopentyl)-essigsaeure-lacton |
