Introduction：Basic information about CAS 10596-23-3|Clodronic Acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Clodronic Acid |
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| CAS Number | 10596-23-3 | Molecular Weight | 244.892 |
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| Density | 2.3±0.1 g/cm3 | Boiling Point | 474.7±55.0 °C at 760 mmHg |
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| Molecular Formula | CH4Cl2O6P2 | Melting Point | 249-251° |
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| MSDS | / | Flash Point | 240.9±31.5 °C |
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Names
| Name | clodronic acid |
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| Synonym | More Synonyms |
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Clodronic Acid BiologicalActivity
| Description | Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Frediani B, et al. Clodronic acid formulations available in Europe and their use in osteoporosis: a review. Clin Drug Investig. 2009;29(6):359-79. |
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Chemical & Physical Properties
| Density | 2.3±0.1 g/cm3 |
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| Boiling Point | 474.7±55.0 °C at 760 mmHg |
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| Melting Point | 249-251° |
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| Molecular Formula | CH4Cl2O6P2 |
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| Molecular Weight | 244.892 |
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| Flash Point | 240.9±31.5 °C |
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| Exact Mass | 243.886017 |
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| PSA | 134.68000 |
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| LogP | -2.38 |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.598 |
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| InChIKey | ACSIXWWBWUQEHA-UHFFFAOYSA-N |
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| SMILES | O=P(O)(O)C(Cl)(Cl)P(=O)(O)O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SZ7640500
- CHEMICAL NAME :
- Phosphonic acid, (dichloromethylene)bis-
- CAS REGISTRY NUMBER :
- 10596-23-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C-H4-Cl2-O6-P2
- MOLECULAR WEIGHT :
- 244.89
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg/4D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,365,1987
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Safety Information
Customs
| HS Code | 2931900090 |
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| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Clodronic Acid |
| methanedichlorodiphosphonic acid |
| Acide clodronique |
| Acidum clodronicum |
| Bonefos |
| Acido clodronico |
| Clodronsaeure |
| Dichloromethylidene diphosphonate |
| (dichloromethylene)bisphosphonic acid |
| [dichloro(phosphono)methyl]phosphonic acid |
| Dichloromethanediphosphonic acid |
| EINECS 234-212-1 |
| dichloromethanediphosphonate |
| dichloro-methylene diphosphonate |
| (dichloromethanediyl)bis(phosphonic acid) |
| (Dichloromethylene)bis(phosphonic acid) |
| Phosphonic acid, (dichloromethylene)bis- |
| P,P'-(Dichloromethylene)Bis-Phosphonic Acid |
| Clodronate |
| dichloromethylenediphosphonic acid |
| Clodronate disodium |
