CAS 10328-92-4|N-Methylisatoic Anhydride
| Common Name | N-Methylisatoic Anhydride | ||
|---|---|---|---|
| CAS Number | 10328-92-4 | Molecular Weight | 177.15700 |
| Density | 1.348 g/cm3 | Boiling Point | 297.5ºC at 760 mmHg |
| Molecular Formula | C9H7NO3 | Melting Point | 165 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 133.7ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-methylisatoic anhydride |
|---|---|
| Synonym | More Synonyms |
N-Methylisatoic Anhydride BiologicalActivity
| Description | N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used forresolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Ursuegui S, et al. Biotin-conjugated N-methylisatoic anhydride: a chemical tool for nucleic acid separation by selective 2'-hydroxyl acylation of RNA. Chem Commun (Camb). 2014 Jun 1;50(43):5748-51. |
Chemical & Physical Properties
| Density | 1.348 g/cm3 |
|---|---|
| Boiling Point | 297.5ºC at 760 mmHg |
| Melting Point | 165 °C (dec.)(lit.) |
| Molecular Formula | C9H7NO3 |
| Molecular Weight | 177.15700 |
| Flash Point | 133.7ºC |
| Exact Mass | 177.04300 |
| PSA | 52.21000 |
| LogP | 0.49170 |
| Vapour density | 6.1 (vs air) |
| Vapour Pressure | 0.00135mmHg at 25°C |
| Index of Refraction | 1.583 |
| Storage condition | -20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 34800 mg/kg
- SEX/DURATION :
- male 8 day(s) pre-mating female 21 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DM3140000 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione |
| N-Methylisatoic Anhydride |
| MFCD00006815 |
| 1-methyl-3,1-benzoxazine-2,4-dione |
| EINECS 233-714-8 |
