Introduction：Basic information about CAS 23095-44-5|Girinimbine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Girinimbine |
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| CAS Number | 23095-44-5 | Molecular Weight | 263.33400 |
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| Density | 1.187g/cm3 | Boiling Point | 450ºC at 760mmHg |
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| Molecular Formula | C18H17NO | Melting Point | / |
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| MSDS | / | Flash Point | 161.5ºC |
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Names
| Name | girinimbine |
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| Synonym | More Synonyms |
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Girinimbine BiologicalActivity
| Description | Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells[1]. Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1].HepG2 cells[1]. Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest[1]. Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 µg/mL[3]. Cell Viability Assay[1] Cell Line: HepG2 cells Concentration: 1 µM, 10 µM, 50 µM, 100 µM, 200 µM Incubation Time: 24 h, 48 h and 72 h Result: Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 56 µM Incubation Time: 24 h, 48 h Result: Showed typical morphological features of apoptosis. Cell Cycle Analysis[1] Cell Line: HepG2 cells Concentration: 56 µM Incubation Time: 12 h, 24 h, 48 h Result: Induced G0/G1-phase arrest in HepG2 cells. |
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| In Vivo | Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2]. In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2]. Animal Model: Male ICR mice (25-35 g) treated with carrageenan[2] Dosage: 10 mg/kg, 30 mg/kg, and 100 mg/kg Administration: Orally gavage; once Result: Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid. |
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| References | [1]. Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16(8):7155-70. [2]. Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121. [3]. H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36(1):94-102. |
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Chemical & Physical Properties
| Density | 1.187g/cm3 |
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| Boiling Point | 450ºC at 760mmHg |
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| Molecular Formula | C18H17NO |
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| Molecular Weight | 263.33400 |
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| Flash Point | 161.5ºC |
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| Exact Mass | 263.13100 |
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| PSA | 25.02000 |
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| LogP | 4.81370 |
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| Vapour Pressure | 7.27E-08mmHg at 25°C |
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| Index of Refraction | 1.68 |
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| InChIKey | GAEQWKVGMHUUKO-UHFFFAOYSA-N |
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| SMILES | Cc1cc2c([nH]c3ccccc32)c2c1OC(C)(C)C=C2 |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| grinimibine |
| Cririnimhin |
| girinbimbine |
