Introduction：Basic information about CAS 55937-99-0|Beclobrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Beclobrate |
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| CAS Number | 55937-99-0 | Molecular Weight | 346.84800 |
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| Density | 1.128g/cm3 | Boiling Point | 437.5ºC at 760mmHg |
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| Molecular Formula | C20H23ClO3 | Melting Point | / |
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| MSDS | / | Flash Point | 149.6ºC |
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Names
| Name | Beclobrate |
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| Synonym | More Synonyms |
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Beclobrate BiologicalActivity
| Description | Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vivo | On the normal diet rats, Beclobrate lowers total plasma cholesterol by 22-33.4% (10-50 mg/kg); the cholesterol reduction occurred mainly in high density lipoproteins (HDL). In addition, Beclobrate administration dramatically increases the activity of the high-affinity receptors for beta-VLDL in isolated liver membranes[1]. |
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| References | [1]. C Manzoni, et al. Differential effects of beclobrate on lipid/lipoprotein distribution in normal and hypercholesterolemic rats. Eur J Pharmacol. 1990 Nov 6;190(1-2):39-49. |
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Chemical & Physical Properties
| Density | 1.128g/cm3 |
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| Boiling Point | 437.5ºC at 760mmHg |
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| Molecular Formula | C20H23ClO3 |
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| Molecular Weight | 346.84800 |
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| Flash Point | 149.6ºC |
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| Exact Mass | 346.13400 |
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| PSA | 35.53000 |
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| LogP | 5.04140 |
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| Index of Refraction | 1.541 |
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| InChIKey | YWQGBCXVCXMSLJ-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)C(C)(CC)Oc1ccc(Cc2ccc(Cl)cc2)cc1 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EK7761040
- CHEMICAL NAME :
- Butanoic acid, 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methyl-, ethyl ester, (+-)-
- CAS REGISTRY NUMBER :
- 55937-99-0
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H23-Cl-O3
- MOLECULAR WEIGHT :
- 346.88
- WISWESSER LINE NOTATION :
- GR D1R DOX2&1&VO2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,237,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4214095
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Safety Information
Customs
| HS Code | 2918990090 |
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| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
