CAS 1072018-68-8|(S)-3,5-DICHLORO-N-((1-((2,2-DIMETHYLTETRAHYDRO-2H-PYRAN-4-YL)METHYL)-4-FLUO

Introduction：Basic information about CAS 1072018-68-8|(S)-3,5-DICHLORO-N-((1-((2,2-DIMETHYLTETRAHYDRO-2H-PYRAN-4-YL)METHYL)-4-FLUO, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(S)-3,5-DICHLORO-N-((1-((2,2-DIMETHYLTETRAHYDRO-2H-PYRAN-4-YL)METHYL)-4-FLUOROPIPERIDIN-4-YL)METHYL)BENZAMIDE
CAS Number1072018-68-8Molecular Weight431.37200
Density/Boiling Point/
Molecular FormulaC21H29Cl2FN2O2Melting Point/
MSDS/Flash Point/

Names

Name3,5-dichloro-N-[[1-[[(4S)-2,2-dimethyloxan-4-yl]methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
SynonymMore Synonyms

BiologicalActivity

DescriptionT-Type calcium channel inhibitor is a potent inhibitor of T-Type calcium channel. T-Type calcium channel inhibitor penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. T-Type calcium channel inhibitor has the potential for the research of neurology disease[1].
Related CatalogSignaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Neurological Disease
References

[1]. Chemin J, et al. De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene. Brain. 2018;141(7):1998-2013.

Chemical & Physical Properties

Molecular FormulaC21H29Cl2FN2O2
Molecular Weight431.37200
Exact Mass430.15900
PSA41.57000
LogP5.06130
InChIKeyDKNDOKIVCXTFHJ-HNNXBMFYSA-N
SMILESCC1(C)CC(CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1

Safety Information

HS Code2934999090

Customs

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

(S)-3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide
Benzamide,3,5-dichloro-N-[[4-fluoro-1-[[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]methyl]-4-piperidinyl]methyl]
(S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide
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