CAS 72822-13-0|Dapiprazole Hydrochloride

Introduction：Basic information about CAS 72822-13-0|Dapiprazole Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dapiprazole Hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Dapiprazole Hydrochloride
CAS Number	72822-13-0	Molecular Weight	361.91
Density	1.2±0.1 g/cm3	Boiling Point	538.9±60.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₈ClN₅	Melting Point	/
MSDS	/	Flash Point	279.7±32.9 °C

Names

Name	3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine,hydrochloride
Synonym	More Synonyms

Dapiprazole Hydrochloride BiologicalActivity

Description	Dapiprazole hydrochloride is a potent α-adrenergic blocking drug, which is used to reverse mydriasis after eye examination.(1) It inhibits amphetamine toxicity and alcohol and morphine withdrawal syndromes, produces sedation, blocks conditioned avoidance reflexes and reduces the response to noxious stimuli.(2) The orally administrated daily dose varied from 30 to 90 mg.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Others
References	[1]. Ramesh T et al.Development and validation of a stability-indicating RP-HPLC assay method and stress degradation studies ondapiprazole. J Chromatogr Sci. 2013 Oct;51(9):856-60. [2]. Marx-Gross S et al. Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels. J Cataract Refract Surg. 2005 Jul;31(7):1372-6.

Description

Dapiprazole hydrochloride is a potent α-adrenergic blocking drug, which is used to reverse mydriasis after eye examination.(1) It inhibits amphetamine toxicity and alcohol and morphine withdrawal syndromes, produces sedation, blocks conditioned avoidance reflexes and reduces the response to noxious stimuli.(2) The orally administrated daily dose varied from 30 to 90 mg.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Others

References

[1]. Ramesh T et al.Development and validation of a stability-indicating RP-HPLC assay method and stress degradation studies ondapiprazole. J Chromatogr Sci. 2013 Oct;51(9):856-60.

[2]. Marx-Gross S et al. Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels. J Cataract Refract Surg. 2005 Jul;31(7):1372-6.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	538.9±60.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₈ClN₅
Molecular Weight	361.91
Flash Point	279.7±32.9 °C
PSA	37.19000
LogP	2.44
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.658
InChIKey	ZIODNPFQZIHCOE-UHFFFAOYSA-N
SMILES	Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1.Cl
Storage condition	-20℃

Synonyms

Rev-Eyes

Dapiprazole hydrochloride

AF 2139

1,2,4-Triazolo[4,3-a]pyridine, 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-

5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine

Dapiprazole

Dapiprazole hydrochloride (USAN)

Dapiprazole HCl

3-{2-[4-(2-Methylphenyl)piperazin-1-yl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

5,6,7,8-Tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine

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