Introduction：Basic information about CAS 57396-78-8|Oroxin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oroxin A |
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| CAS Number | 57396-78-8 | Molecular Weight | 432.378 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 784.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C21H20O10 | Melting Point | / |
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| MSDS | / | Flash Point | 279.0±26.4 °C |
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Names
| Name | 5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranoside |
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| Synonym | More Synonyms |
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Oroxin A BiologicalActivity
| Description | Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>PARPResearch Areas >>Metabolic DiseaseSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| In Vitro | Oroxin A (0.5- 100 μM; 24 hours) significantly increases the PPARγ transcription level and exhibits the strongest activation with 50 μM in HEK-293t cells[1]. |
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| References | [1]. Sun W, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice. Phytomedicine. 2018 Jan 1;38:24-34. [2]. He J, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anticancer Drugs. 2016 Mar;27(3):204-15. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 784.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C21H20O10 |
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| Molecular Weight | 432.378 |
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| Flash Point | 279.0±26.4 °C |
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| Exact Mass | 432.105652 |
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| PSA | 170.05000 |
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| LogP | 0.47 |
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| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
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| Index of Refraction | 1.717 |
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| InChIKey | IPQKDIRUZHOIOM-IAAKTDFRSA-N |
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| SMILES | O=c1cc(-c2ccccc2)oc2cc(OC3OC(CO)C(O)C(O)C3O)c(O)c(O)c12 |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| 5,6-dihydroxyflavone-7-glucoside |
| B-Aethyl-boracycloheptan |
| 5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranoside |
| 1-ethyl-borepane |
| 4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5,6-dihydroxy-2-phenyl- |
| baicalein-7-O-glucoside |
| Borepane,1-ethyl |
| Baicalein 7-b-D-glucopyranoside |
| Oroxin A |
