CAS 10500-64-8|Hydroxychloroquine Impurity E

Introduction：Basic information about CAS 10500-64-8|Hydroxychloroquine Impurity E, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Hydroxychloroquine Impurity E BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Hydroxychloroquine Impurity E
CAS Number	10500-64-8	Molecular Weight	264.75100
Density	1.248g/cm3	Boiling Point	453.7ºC at 760 mmHg
Molecular Formula	C₁₄H₁₇ClN₂O	Melting Point	179-181 ºC
MSDS	/	Flash Point	/

Names

Name	4-[(7-chloroquinolin-4-yl)amino]pentan-1-ol
Synonym	More Synonyms

Hydroxychloroquine Impurity E BiologicalActivity

Description	Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Description

Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Chemical & Physical Properties

Density	1.248g/cm3
Boiling Point	453.7ºC at 760 mmHg
Melting Point	179-181 ºC
Molecular Formula	C₁₄H₁₇ClN₂O
Molecular Weight	264.75100
Exact Mass	264.10300
PSA	45.15000
LogP	3.53410
Vapour Pressure	5.08E-09mmHg at 25°C
Index of Refraction	1.643
InChIKey	BZUKCXDUDOUBKN-UHFFFAOYSA-N
SMILES	CC(CCCO)Nc1ccnc2cc(Cl)ccc12
Water Solubility	Practically insoluble (0.087 g/L) (25 ºC)

Safety Information

HS Code	2933499090

Customs

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

GNF-Pf-1978

4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol

Plaquenil Impurity 1

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