Introduction：Basic information about CAS 87827-02-9|3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine |
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| CAS Number | 87827-02-9 | Molecular Weight | 315.450 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 461.0±35.0 °C at 760 mmHg |
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| Molecular Formula | C20H29NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 232.6±25.9 °C |
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Names
| Name | 2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Inflammation/Immunology |
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| Target | NF-κB |
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| References | [1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. [2]. Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 461.0±35.0 °C at 760 mmHg |
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| Molecular Formula | C20H29NO2 |
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| Molecular Weight | 315.450 |
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| Flash Point | 232.6±25.9 °C |
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| Exact Mass | 315.219818 |
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| PSA | 32.70000 |
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| LogP | 3.44 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.588 |
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| InChIKey | GTKRIWMDLNOSLI-UHFFFAOYSA-N |
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| SMILES | OC(COC1CN2CCC1CC2)(c1ccccc1)C1CCCC1 |
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Synonyms
| 2-(1-Azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol |
| Benzenemethanol, α-((1-azabicyclo(2.2.2)oct-3-yloxy)methyl)-α-cyclopentyl- |
| UNII:353CX8CSHD |
| Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl- |
| m 8218 |
| 3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine |
