CAS 1285702-20-6|ML-167

Introduction：Basic information about CAS 1285702-20-6|ML-167, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ML-167 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	ML-167
CAS Number	1285702-20-6	Molecular Weight	335.357
Density	1.3±0.1 g/cm3	Boiling Point	531.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇N₃O₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	275.4±28.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
Synonym	More Synonyms

ML-167 BiologicalActivity

Description	ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.
Related Catalog	Research Areas >>Cancer
Target	Clk4:136 nM (IC50) CLK1:1522 nM (IC50) Clk2:1648 nM (IC50) Dyrk1B:4420 nM (IC50)
References	[1]. Rosenthal AS, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4).

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	531.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇N₃O₃
Molecular Weight	335.357
Flash Point	275.4±28.7 °C
Exact Mass	335.126984
PSA	75.53000
LogP	2.68
Appearance of Characters	off-white to gray to brown
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.679
InChIKey	ROCFOIBAEVAOLQ-UHFFFAOYSA-N
SMILES	Cc1ccc(CNc2ncnc3ccc(-c4ccc(CO)o4)cc23)o1
Storage condition	?20°C
Water Solubility	DMSO: soluble10mg/mL, clear

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	46
RIDADR	NONH for all modes of transport

Synonyms

[5-(4-{[(5-Methyl-2-furyl)methyl]amino}-6-quinazolinyl)-2-furyl]methanol

2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-

[5-[4-[methyl-(5-methylfuran-2-yl)amino]quinazolin-6-yl]furan-2-yl]methanol

ML167

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