CAS 194423-15-9|PD168393
Introduction：Basic information about CAS 194423-15-9|PD168393, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PD168393 | ||
|---|---|---|---|
| CAS Number | 194423-15-9 | Molecular Weight | 369.215 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 571.1±50.0 °C at 760 mmHg |
| Molecular Formula | C17H13BrN4O | Melting Point | 279℃ |
| MSDS | USA | Flash Point | 299.2±30.1 °C |
Names
| Name | N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide |
|---|---|
| Synonym | More Synonyms |
PD168393 BiologicalActivity
| Description | PD168393 is an potent, cell-permeable, irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773, inactive against insulin, PDGFR, FGFR and PKC. target: EGFRIC 50: 0.7 nM [1](1) PD 168393 inhibite EGFr autophosphorylation in A431 human epidermoid carcinoma cells with >9-fold greater potency than PD 174265.[1](2) PD 168393 decrease the production of TNF-α and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes.[2](3) PD168393 completely inhibits AKT and ERK phosphorylation at concentrations as low as 0.03 umol/L.[3](4) PD168393 could induce apoptosis and inhibit cell growth in ErbB2 positive lung and breast cancer cell lines.[3](5) PD168393 disrupted MEK1/p44/42 ERK signaling in HaCaT cells as determined by inhibition of phospho-p44/42 ERK. [4] |
|---|---|
| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Cancer |
| Target | EGFR:0.7 nM (IC50) |
| References | [1]. Fry DW et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. [2]. Sun X et al. The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. Oncotarget. 2015 Nov 3;6(34):35478-95. [3]. Li G et al. Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 Mutations and PHLDA1. PLoS One. 2014 Sep 19;9(9):e106349. [4]. White KJ et al. Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation. J Invest Dermatol. 2011 Feb;131(2):435-42. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 571.1±50.0 °C at 760 mmHg |
| Melting Point | 279℃ |
| Molecular Formula | C17H13BrN4O |
| Molecular Weight | 369.215 |
| Flash Point | 299.2±30.1 °C |
| Exact Mass | 368.027252 |
| PSA | 70.40000 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.744 |
| InChIKey | HTUBKQUPEREOGA-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 |
| Storage condition | -20°C |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Synonyms
| 2-Propenamide (N-[4-[(3-bromophenyl)amino]-6-quinazolinyl] |
| nchembio866-comp2 |
| pd 168393 |
| 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- |
| N-{4-[(3-Bromophenyl)amino]-6-quinazolinyl}acrylamide |
| PD168393 |
