CAS 41107-56-6|2′,3′-Dideoxy-3′-fluorouridine
| Common Name | 2′,3′-Dideoxy-3′-fluorouridine | ||
|---|---|---|---|
| CAS Number | 41107-56-6 | Molecular Weight | 230.19 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C9H11FN2O4 | Melting Point | 184-188ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Warning |
Names
| Name | 2',3'-dideoxy-3'-fluorouridine |
|---|---|
| Synonym | More Synonyms |
2′,3′-Dideoxy-3′-fluorouridine BiologicalActivity
| Description | 2′,3′-Dideoxy-3′-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Melting Point | 184-188ºC(lit.) |
| Molecular Formula | C9H11FN2O4 |
| Molecular Weight | 230.19 |
| Exact Mass | 230.070282 |
| PSA | 84.32000 |
| LogP | -1.11 |
| Index of Refraction | 1.577 |
| InChIKey | BKIUEHLYJFLWPK-SHYZEUOFSA-N |
| SMILES | O=c1ccn(C2CC(F)C(CO)O2)c(=O)[nH]1 |
| Storage condition | -20°C |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H341 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R68 |
| Safety Phrases | 22-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| HS Code | 29349990 |
Articles6
More Articles| Synthesis and in vitro antiviral activities of 3'-fluoro (or chloro) and 2',3'-difluoro 2',3'-dideoxynucleoside analogs against hepatitis B and C viruses. Bioorg. Med. Chem. 18(21) , 7542-7, (2010) Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) lead to serious liver diseases worldwide. Co-infection with HBV and HCV is very common and is associated with increased risk... | |
| Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J. Biol. Chem. 264 , 6127, (1989) 3'-Azido-2',3'-dideoxythymidine (AZT) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus replication in MT-4 and ATH8 cells. They are ... | |
| Perspectives for the chemotherapy of AIDS. Chemioterapia 7(6) , 357-64, (1988) Several steps in the replicative cycle of human immunodeficiency virus (HIV) could be envisaged as targets for anti-AIDS drugs. The anionic compound PMEA [9-(2-phosphonyl-methoxyethyl)adenine], the 2'... |
Synonyms
| 1-(2,3-dideoxy-3-fluoropentofuranosyl)pyrimidine-2,4(1H,3H)-dione |
| Fddurd |
| URIDINE,2',3'-DIDEOXY-3'-FLUORO |
| 2,4(1H,3H)-Pyrimidinedione, 1-(2,3-dideoxy-3-fluoropentofuranosyl)- |
| 5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine)-3-fluoro-2-hydroxymethyltetrahydrofuran |
| 1-(2,3-Dideoxy-3-fluoropentofuranosyl)-2,4(1H,3H)-pyrimidinedione |
| EINECS 415-360-8 |
| 3'-FLUORO-2',3'-DIDEOXYURIDINE |
| MFCD00192015 |
| 2'3'-dideoxy-3'-fluorouridine |
