CAS 627-63-4|Fumaryl chloride

Introduction：Basic information about CAS 627-63-4|Fumaryl chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles5
7. Synonyms

Common Name	Fumaryl chloride
CAS Number	627-63-4	Molecular Weight	152.96300
Density	1.415 g/mL at 25 °C(lit.)	Boiling Point	161-164 °C(lit.)
Molecular Formula	C₄H₂Cl₂O₂	Melting Point	-2 °C
MSDS	ChineseUSA	Flash Point	165 °F
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	Fumaryl chloride
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.415 g/mL at 25 °C(lit.)
Boiling Point	161-164 °C(lit.)
Melting Point	-2 °C
Molecular Formula	C₄H₂Cl₂O₂
Molecular Weight	152.96300
Flash Point	165 °F
Exact Mass	151.94300
PSA	34.14000
LogP	1.07340
Index of Refraction	n20/D 1.499(lit.)
InChIKey	ZLYYJUJDFKGVKB-OWOJBTEDSA-N
SMILES	O=C(Cl)C=CC(=O)Cl
Storage condition	Refrigerator (+4°C)
Water Solubility	decomposes

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LT2800000

CHEMICAL NAME :: Fumaryl chloride

CAS REGISTRY NUMBER :: 627-63-4

BEILSTEIN REFERENCE NO. :: 1721342

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H2-Cl2-O2

MOLECULAR WEIGHT :: 152.96

WISWESSER LINE NOTATION :: GV1U1VG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,327,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,327,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 810 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/m3/10M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Musculoskeletal - other changes

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,MAY1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1410 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302 + H312 + H332-H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C:Corrosive;
Risk Phrases	R20/21/22;R29;R34
Safety Phrases	S26-S36/37/39-S45-S8
RIDADR	UN 1780 8/PG 2
WGK Germany	3
RTECS	LT2800000
Packaging Group	II
Hazard Class	8
HS Code	29171990

Customs

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles5

Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger.

J. Biomater. Sci. Polym. Ed. 10(3) , 363-73, (1999)

To synthesize high molecular weight poly(propylene fumarate) (PPF), fumaryl chloride and propylene glycol were reacted in the presence of potassium carbonate, which serves as a proton scavenger. Trans...

Dynamics of Cl (2Pj) atom formation in the photodissociation of fumaryl chloride (ClCO - CH = CH - COCl) at 235 nm: a resonance enhanced multiphoton ionization (REMPI) time-of-flight (TOF) study.

J. Phys. Chem. A 115(9) , 1538-46, (2011)

The photodissociation dynamics of fumaryl chloride (ClCO-CH═CH-COCl) has been studied in a supersonic molecular beam around 235 nm using resonance enhanced multiphoton ionization (REMPI) time-of-fligh...

Synthesis of oligo(poly(ethylene glycol) fumarate).

Nat. Protoc. 7(6) , 1219-27, (2012)

This protocol describes the synthesis of oligo(poly(ethylene glycol) fumarate) (OPF; 1-35 kDa; a polymer useful for tissue engineering applications) by a one-pot reaction of poly(ethylene glycol) (PEG...

Synonyms

n-Butyl fumarate

fumaroyl chloride

MFCD00000733

Fumarsaeure-mono-n-butylester

fumaroyl dichloride

EINECS 211-005-4

fumaric acid chloroanhydride

Fumaric acid dichloride

Monobutyl fumarate

fumaric acid dichloroanhydride

mono-n-butyl maleate

Fumaric acid,butyl ester

Fumaric acid monobutyl ester

but-2-enedioyl dichloride

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