Introduction：Basic information about CAS 2306-27-6|Sinensetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. [3]
[1]. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8.
[2]. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9.
[3]. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56.
Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
547.8±50.0 °C at 760 mmHg
Melting Point
174-176ºC
Molecular Formula
C20H20O7
Molecular Weight
372.369
Flash Point
240.6±30.2 °C
Exact Mass
372.120911
PSA
76.36000
LogP
3.08
Vapour Pressure
0.0±1.5 mmHg at 25°C
Index of Refraction
1.566
InChIKey
LKMNXYDUQXAUCZ-UHFFFAOYSA-N
SMILES
COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1OC
Storage condition
2-8°C
Safety Information
Symbol
GHS06
Signal Word
Danger
Hazard Statements
H301
Precautionary Statements
P301 + P310
Hazard Codes
T
Risk Phrases
25
Safety Phrases
22-24/25
RIDADR
UN 2811 6.1 / PGIII
HS Code
2914509090
Customs
HS Code
2914509090
Summary
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles1
More Articles
Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes.
Biol. Pharm. Bull. 38(4) , 552-8, (2015)
Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted ad...
