CAS 17306-46-6|Rhoifolin
| Common Name | Rhoifolin | ||
|---|---|---|---|
| CAS Number | 17306-46-6 | Molecular Weight | 578.519 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 916.5±65.0 °C at 760 mmHg |
| Molecular Formula | C27H30O14 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 305.4±27.8 °C |
Names
| Name | apigenin 7-O-neohesperidoside |
|---|---|
| Synonym | More Synonyms |
Rhoifolin BiologicalActivity
| Description | Rhoifolin is a flavone glycoside isolated from Citrus grandis (L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation[1]. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Metabolic DiseaseSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Insulin Receptor |
| Target | NF-κB insulin receptor-β MAPK |
| References | [1]. Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375. [2]. Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 916.5±65.0 °C at 760 mmHg |
| Molecular Formula | C27H30O14 |
| Molecular Weight | 578.519 |
| Flash Point | 305.4±27.8 °C |
| Exact Mass | 578.163574 |
| PSA | 228.97000 |
| LogP | 1.72 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.726 |
| InChIKey | RPMNUQRUHXIGHK-PYXJVEIZSA-N |
| SMILES | CC1OC(OC2C(Oc3cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc4c3)OC(CO)C(O)C2O)C(O)C(O)C1O |
| Storage condition | 0-6°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles5
More Articles| Study on impurities in naringin extracted from Citrus grandis 'tomentosa'. Zhong Yao Cai 35(1) , 56-61, (2012) To investigate the impurities in naringin extracted from Citrus grandis 'Tomentosa'.High performance liquid chromatographies coupled with photodiode array and electrospray ionization mass spectrometry... | |
| Determination of rhoifolin and daidzin in human plasma by high-performance liquid chromatography. J. Chromatogr. B, Biomed. Appl. 655(2) , 300-4, (1994) A method for determining flavonoids in human plasma is presented for application to pharmacokinetic studies of two flavonoids, rhoifolin and daidzin. Isocratic reversed-phase high-performance liquid c... | |
| [Studies on antibacterial constituents of Discocleidion rufescens (2)]. Zhongguo Zhong Yao Za Zhi 34 , 1377-1380, (2009) To screen effective constituents of Discocleidion rufescens against bacteria.Compounds were isolated by bioassay-guided fractionation method with various chromatographic methods and their structures w... |
Synonyms
| Apigenin-7-O-neohesperidoside |
| Apigenin-7-neohesperidoside |
| RHOIFOLOSIDE |
| 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-on |
| 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)- |
| 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxyméthyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphényl)-4H-chromén-4-one |
| Apigenin 7-O-neo-hesperidoside |
| 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside |
| 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-oxy]-5-hydroxy-2-(4-hydroxyphenyl)- |
| 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside |
| apigenin 7-O-neohesperidoside |
| Rhoifolin |
| Apigenin-7-rhamnoglucoside |
| 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside |
| 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)- |
