CAS 81382-51-6|Pentiapine

Introduction：Basic information about CAS 81382-51-6|Pentiapine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pentiapine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Pentiapine
CAS Number	81382-51-6	Molecular Weight	299.39400
Density	/	Boiling Point	/
Molecular Formula	C₁₅H₁₇N₅S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	5-(4-methylpiperazin-1-yl)imidazo[2,1-b][1,3,5]benzothiadiazepine
Synonym	More Synonyms

Pentiapine BiologicalActivity

Description	Pentiapine is a novel dopamine release inhibitor.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
Target	Dopamine receptor[1]
In Vivo	Pentiapine is a novel dopamine release inhibitor.The results show that Pentiapine dose-dependently reduces motor activity of mice. Moreover, Pentiapine dose-dependently reduces morphine-induced hyperactivity. Newman-Keuls post-hoc comparisons indicate that the group receiving morphine plus saline presents more activity than the groups receiving morphine plus 2 (P<0.05), 4, 8, 16, 24 and 32 (P<0.01) mg/kg of Pentiapine. Moreover, the groups receiving morphine plus 0.5, 1 and 2 mg/kg of Pentiapine present more activity than the groups receiving morphine plus 4, 8, 16, 24 and 32 mg/kg of Pentiapine (P<0.01)[1]. 30 mg/kg dose of Pentiapine completely blocks the methylenedioxymethamphetamine (MDMA) conditioned place preference (CPP) and also blocks the establishment of a cocaine CPP[2].
Animal Admin	Two hundred and fifty-seven male mice are used in this study. Animals are divided into 19 groups (n=8). The first group receives physiological saline, the second receives 40 mg/kg of morphine and the other eight groups receive 0.5, 1, 2, 4, 8, 16, 24 or 32 mg/kg of Pentiapine, respectively. The remaining groups receive an injection of morphine and 30 min afterwards, an injection of physiological saline, 0.5, 1, 2, 4, 8, 16, 24 or 32 mg/kg of Pentiapine, respectively. In the groups receiving only one injection, animals are placed onto the sensory plates for a period of 90 min immediately after treatment. The computer registers the activity each 15 min. In the groups receiving two injections, animals are placed onto the sensory plates immediately after the first injection for a period of 30 min then after the second injection the motor activity is registered at 15, 30, 45 and 60 min[1].
References	[1]. Manzanedo C, et al. Effects of CGS 10746B on hyperactivity and place preference induced by morphine. Behav Brain Res. 2001 Nov 29;126(1-2):23-32. [2]. Bilsky EJ, et al. CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences. Pharmacol Biochem Behav. 1998 Jan;59(1):215-20.

Chemical & Physical Properties

Molecular Formula	C₁₅H₁₇N₅S
Molecular Weight	299.39400
Exact Mass	299.12000
PSA	61.96000
LogP	1.44230
InChIKey	FACMWMBWGSPRKO-UHFFFAOYSA-N
SMILES	CN1CCN(C2=Nc3ccccc3Sc3nccn32)CC1
Storage condition	2-8℃

Synonyms

Pentiapine [INN]

UNII-RAP39VD6P5

5-(4-methyl-1-piperazinyl)imidazo[2,1-b][1,3,5]benzothiadiazepine

PENTIAPINE MALEATE

Pentiapine

5-(4-methylpiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine

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