Introduction：Basic information about CAS 17643-36-6|9-Decyn-1-ol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 9-Decyn-1-ol |
|---|
| CAS Number | 17643-36-6 | Molecular Weight | 154.249 |
|---|
| Density | 0.9±0.1 g/cm3 | Boiling Point | 232.1±23.0 °C at 760 mmHg |
|---|
| Molecular Formula | C10H18O | Melting Point | / |
|---|
| MSDS | / | Flash Point | 171.8±14.9 °C |
|---|
Names
| Name | dec-9-yn-1-ol |
|---|
| Synonym | More Synonyms |
|---|
9-Decyn-1-ol BiologicalActivity
| Description | 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
|---|
| Target | Alkyl/ether |
|---|
| In Vitro | 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1]. |
|---|
| References | [1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. |
|---|
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|
| Boiling Point | 232.1±23.0 °C at 760 mmHg |
|---|
| Molecular Formula | C10H18O |
|---|
| Molecular Weight | 154.249 |
|---|
| Flash Point | 171.8±14.9 °C |
|---|
| Exact Mass | 154.135757 |
|---|
| PSA | 20.23000 |
|---|
| LogP | 2.71 |
|---|
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
|---|
| Index of Refraction | 1.458 |
|---|
| InChIKey | KOAOUMQUUZNRLL-UHFFFAOYSA-N |
|---|
| SMILES | C#CCCCCCCCCO |
|---|
Safety Information
Customs
| HS Code | 2905290000 |
|---|
| Summary | 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
|---|
Synonyms
| 10-Hydroxy-1-decyne |
| dec-9-yn-1-ol |
| 9-Decyn-1-ol |
