CAS 486-39-5|Coclaurine

Introduction：Basic information about CAS 486-39-5|Coclaurine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Coclaurine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Coclaurine
CAS Number	486-39-5	Molecular Weight	285.338
Density	1.2±0.1 g/cm3	Boiling Point	496.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₉NO₃	Melting Point	220-221°
MSDS	/	Flash Point	254.3±28.7 °C

Names

Name	(RS)-coclaurine
Synonym	More Synonyms

Coclaurine BiologicalActivity

Description	Coclaurine is a class of tetrahydroisoquinoline alkaloids isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChR
References	[1]. Sowemimo BO, et al. The isolation of stepharine and coclaurine from Sarcopetalum harveyanum. Lloydia. 1972 Mar;35(1):90-1. [2]. Matthew J. Cheesman . Oceania: Antidepressant Medicinal Plants. Herbal Medicine in Depression. 2016, 483-527.

Description

Coclaurine is a class of tetrahydroisoquinoline alkaloids isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChR

References

[1]. Sowemimo BO, et al. The isolation of stepharine and coclaurine from Sarcopetalum harveyanum. Lloydia. 1972 Mar;35(1):90-1.

[2]. Matthew J. Cheesman . Oceania: Antidepressant Medicinal Plants. Herbal Medicine in Depression. 2016, 483-527.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	496.9±45.0 °C at 760 mmHg
Melting Point	220-221°
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.338
Flash Point	254.3±28.7 °C
Exact Mass	285.136505
PSA	61.72000
LogP	1.72
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.621
InChIKey	LVVKXRQZSRUVPY-HNNXBMFYSA-N
SMILES	COc1cc2c(cc1O)C(Cc1ccc(O)cc1)NCC2

Safety Information

Hazard Codes	Xi

Synonyms

(1S)-1-(4-Hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydro-7-isoquinolinol

Coclaurine

1-(4-Hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol

Isoquinolin-7-ol, 1-[4-hydroxybenzyl]-1,2,3,4-tetrahydro-6-methoxy-

1-(4-Hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydro-7-isoquinolinol

7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-, (1S)-

Machiline

1-(p-Hydroxybenzyl)-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline

1,2,3,4-Tetrahydro-1-(p-hydroxybenzyl)-6-methoxy-7-isoquinolinol

7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-

6-Methoxy-7-hydroxy-(1R)-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline

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