CAS 23500-15-4|Captopril EP Impurity E

Introduction：Basic information about CAS 23500-15-4|Captopril EP Impurity E, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Captopril EP Impurity E BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Captopril EP Impurity E
CAS Number	23500-15-4	Molecular Weight	185.22000
Density	/	Boiling Point	/
Molecular Formula	C₉H₁₅NO₃	Melting Point	122.6-123.7℃
MSDS	/	Flash Point	/

Names

Name	(2S)-1-(2-methylpropanoyl)pyrrolidine-2-carboxylic acid
Synonym	More Synonyms

Captopril EP Impurity E BiologicalActivity

Description	Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL. [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Description

Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Chemical & Physical Properties

Melting Point	122.6-123.7℃
Molecular Formula	C₉H₁₅NO₃
Molecular Weight	185.22000
Exact Mass	185.10500
PSA	57.61000
LogP	0.65590
InChIKey	WKQUFVTUGGLNNO-ZETCQYMHSA-N
SMILES	CC(C)C(=O)N1CCCC1C(=O)O

Synonyms

L-Proline,1-(2-methyl-1-oxopropyl)

(2S)-1-(2-Methylpropanoyl)pyrrolidine-2-carboxylic acid,1-Isobutyryl-L-proline

UNII-27JC6R80S1

L-1-Isobutyrylproline

Captopril Impurity 6

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