CAS 22662-39-1|Rafoxanide

Introduction：Basic information about CAS 22662-39-1|Rafoxanide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Rafoxanide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Preparation
7. Customs
8. Articles25
9. Synonyms

Common Name	Rafoxanide
CAS Number	22662-39-1	Molecular Weight	626.010
Density	2.0±0.1 g/cm3	Boiling Point	526.6±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₁Cl₂I₂NO₃	Melting Point	169ºC
MSDS	ChineseUSA	Flash Point	272.3±30.1 °C

Names

Name	Rafoxanide
Synonym	More Synonyms

Rafoxanide BiologicalActivity

Description	Rafoxanide is a salicylanilide used as an antiparasitic agent.
Related Catalog	Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection

Chemical & Physical Properties

Density	2.0±0.1 g/cm3
Boiling Point	526.6±50.0 °C at 760 mmHg
Melting Point	169ºC
Molecular Formula	C₁₉H₁₁Cl₂I₂NO₃
Molecular Weight	626.010
Flash Point	272.3±30.1 °C
Exact Mass	624.820496
PSA	58.56000
LogP	9.36
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.753
InChIKey	NEMNPWINWMHUMR-UHFFFAOYSA-N
SMILES	O=C(Nc1ccc(Oc2ccc(Cl)cc2)c(Cl)c1)c1cc(I)cc(I)c1O
Storage condition	0-6°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN7870000

CHEMICAL NAME :: Salicylanilide, 3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodo-

CAS REGISTRY NUMBER :: 22662-39-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H11-Cl2-I2-N-O3

MOLECULAR WEIGHT :: 626.01

WISWESSER LINE NOTATION :: QR BI DI FVMR CG DOR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: REMVAY Revue d'Elevage et de Medicine Veterinaire des Pays Tropicaux. (Editions Vigot, 23 rue de l'Ecole-de-Medecine, F-75006 Paris, France) V.1- 1947- Volume(issue)/page/year: 29,31,1976

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	VN7870000
HS Code	2924299090

Preparation

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles25

The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity.

J. Parasitol. 90(4) , 898-9, (2004)

A novel laboratory anticestode assay was developed using Hymenolepis diminuta in the hamster. The commercial anticestode compounds, praziquantel, bunamidine, and niclosamide were active against patent...

An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Toxicol. Lett. 208(1) , 30-5, (2012)

A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the...

Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS.

J. Sep. Sci. 33(2) , 206-11, (2010)

A sensitive and selective LC-FLD method was described for determination of closantel and rafoxanide in bovine and ovine muscles. Bovine and ovine muscles were extracted with ACN and acetone mixture (8...

Synonyms

N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide

EINECS 245-148-9

N-[3-Chlor-4-(4-chlorphenoxy)phenyl]-2-hydroxy-3,5-diiodbenzolcarboxamid

MFCD00682899

Rafoxanide

3'-Chloro-4'-(4-chlorophenoxy)-3,5-diiodosalicylanilide

3’-chloro-4’-(4-chlorophenoxy)-3,5-diiodosalicylanilide

Benzamide, N-(3-chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodo-

Benzamide, N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-

3'-Chlor-4'-<4-chlor-phenoxy>-3,5-dijod-salicyl-anilid

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