Introduction：Basic information about CAS 100490-36-6|Tosufloxacin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tosufloxacin |
|---|
| CAS Number | 100490-36-6 | Molecular Weight | 404.34300 |
|---|
| Density | 1.558g/cm3 | Boiling Point | 614.4ºC at 760 mmHg |
|---|
| Molecular Formula | C19H15F3N4O3 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 325.4ºC |
|---|
Names
| Name | tosufloxacin tosilate |
|---|
| Synonym | More Synonyms |
|---|
Tosufloxacin BiologicalActivity
| Description | Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
|---|
| In Vitro | Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens[2]. Cell Viability Assay[2] Cell Line: S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens Concentration: 0.05-3.13 μg/mL Incubation Time: 18 hours Result: Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci. Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively. |
|---|
| In Vivo | Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2]. Animal Model: Male Slc:ICR mice infected with S. aureus[2] Dosage: 1.27-2.15 mg/kg Administration: Oral gavage; 1.27-2.15 mg/kg; once Result: Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL. Animal Model: Male Slc:ICR mice infected with E. coli[2] Dosage: 0.16-0.30 mg/kg Administration: Oral gavage; 0.16-0.30 mg/kg; once Result: Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL. Animal Model: Male Slc:ICR mice infected with P. aeruginosa[2] Dosage: 7.66-13.39 mg/kg Administration: Oral gavage; 7.66-13.39 mg/kg; once Result: Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.78 μg/mL. |
|---|
Chemical & Physical Properties
| Density | 1.558g/cm3 |
|---|
| Boiling Point | 614.4ºC at 760 mmHg |
|---|
| Molecular Formula | C19H15F3N4O3 |
|---|
| Molecular Weight | 404.34300 |
|---|
| Flash Point | 325.4ºC |
|---|
| Exact Mass | 404.11000 |
|---|
| PSA | 101.45000 |
|---|
| LogP | 2.80390 |
|---|
| Vapour Pressure | 5.96E-16mmHg at 25°C |
|---|
| InChIKey | WUWFMDMBOJLQIV-UHFFFAOYSA-N |
|---|
| SMILES | NC1CCN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)C1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- QN2791990
- CHEMICAL NAME :
- 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-(2,4- difluorophenyl)-6-fluoro-4-oxo-
- CAS REGISTRY NUMBER :
- 100490-36-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C19-H15-F3-N4-O3
- MOLECULAR WEIGHT :
- 404.38
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993
|
Safety Information
| Hazard Codes | Xi |
|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
|---|
| Safety Phrases | S26-S37/39 |
|---|
| WGK Germany | 3 |
|---|
Synonyms
| Toskisasin |
| TOSUFLOXACIN |
| TFLX |
| Ozex |
| MFCD01711971 |
| TETRAETHYL AMMONIUM IODIDE |
| TOSUFLOXACIN, ANTIBIOTIC FOR CULTURE MEDIA USE ONLY |
| 1,8-NAPHTHYRIDINE-3-CARBOXYLICACID,7-(3-AMINO-1-PYRROLIDINYL)-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-1,4-DIHYDRO-4-OXO- |
