Introduction：Basic information about CAS 949912-58-7|Remodelin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Remodelin |
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| CAS Number | 949912-58-7 | Molecular Weight | 282.363 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 498.9±47.0 °C at 760 mmHg |
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| Molecular Formula | C15H14N4S | Melting Point | / |
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| MSDS | USA | Flash Point | 255.5±29.3 °C |
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Names
| Name | Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl] |
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| Synonym | More Synonyms |
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Remodelin BiologicalActivity
| Description | Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.IC50 value:Target: NAT10 inhibitorRemodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>Histone AcetyltransferaseResearch Areas >>Cancer |
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| References | [1]. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 498.9±47.0 °C at 760 mmHg |
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| Molecular Formula | C15H14N4S |
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| Molecular Weight | 282.363 |
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| Flash Point | 255.5±29.3 °C |
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| Exact Mass | 282.093903 |
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| PSA | 89.31000 |
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| LogP | 2.16 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.702 |
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| InChIKey | XAEJIFARBQJLML-UHFFFAOYSA-N |
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| SMILES | N#Cc1ccc(-c2csc(NN=C3CCCC3)n2)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]- |
| 4-[2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl]benzonitrile |
| 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile |
| Remodelin |
