CAS 74513-62-5|Trimegestone

Introduction：Basic information about CAS 74513-62-5|Trimegestone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Trimegestone BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Trimegestone
CAS Number	74513-62-5	Molecular Weight	342.47
Density	1.2±0.1 g/cm3	Boiling Point	522.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₃	Melting Point	/
MSDS	/	Flash Point	284.0±26.6 °C

Names

Name	Trimegestone
Synonym	More Synonyms

Trimegestone BiologicalActivity

Description	Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes[1][2].
Related Catalog	Signaling Pathways >>Others >>Progesterone ReceptorSignaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>EndocrinologySignaling Pathways >>Others >>Androgen Receptor
References	[1]. Wahab M, et al. Trimegestone: expanding therapeutic choices for the treatment of the menopause. Expert Opin Investig Drugs. 2001 Sep;10(9):1737-44. [2]. Zhang Z, et al. In vitro characterization of trimegestone: a new potent and selective progestin. Steroids. 2000 Oct-Nov;65(10-11):637-43.

Description

Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes[1][2].

Related Catalog

Signaling Pathways >>Others >>Progesterone ReceptorSignaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>EndocrinologySignaling Pathways >>Others >>Androgen Receptor

References

[1]. Wahab M, et al. Trimegestone: expanding therapeutic choices for the treatment of the menopause. Expert Opin Investig Drugs. 2001 Sep;10(9):1737-44.

[2]. Zhang Z, et al. In vitro characterization of trimegestone: a new potent and selective progestin. Steroids. 2000 Oct-Nov;65(10-11):637-43.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	522.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₃
Molecular Weight	342.47
Flash Point	284.0±26.6 °C
Exact Mass	342.219482
PSA	54.37000
LogP	3.58
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.569
InChIKey	JUNDJWOLDSCTFK-MTZCLOFQSA-N
SMILES	CC(O)C(=O)C1(C)CCC2C3CCC4=CC(=O)CCC4=C3CCC21C

Synonyms

(8S,13S,14S,17S)-17-[(2S)-2-Hydroxypropanoyl]-13,17-dimethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

17β-(S)-Lactoyl-17-methylestra-4,9-dien-3-one

(8S,13S,14S,17S)-17-[(2S)-2-Hydroxypropanoyl]-13,17-dimethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)

Trimegestone

trimebutinemaleate

Estra-4,9-dien-3-one, 17-[(2S)-2-hydroxy-1-oxopropyl]-17-methyl-, (17β)-

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