CAS 100930-11-8|[D-Trp2,7,9]-Substance P
Introduction：Basic information about CAS 100930-11-8|[D-Trp2,7,9]-Substance P, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | [D-Trp2,7,9]-Substance P | ||
|---|---|---|---|
| CAS Number | 100930-11-8 | Molecular Weight | 1604.92000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C80H109N21O13S | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | [D-Trp2,7,9]-Substance P |
|---|---|
| Synonym | More Synonyms |
[D-Trp2,7,9]-Substance P BiologicalActivity
| Description | [D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with Ki values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor |
| Target | NK1:1 μM (Ki) NK2:1.3 μM (Ki) NK3:~9 μM (Ki) |
| References | [1]. S H Buck, et al. Agonist and antagonist binding to tachykinin peptide NK-2 receptors. Life Sci. 1988;42(26):2701-8. |
Chemical & Physical Properties
| Molecular Formula | C80H109N21O13S |
|---|---|
| Molecular Weight | 1604.92000 |
| Exact Mass | 1603.82000 |
| PSA | 598.09000 |
| LogP | 8.43880 |
| InChIKey | YKBGUHRGZVONNE-KXXNZUQNSA-N |
| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(N)CCCNC(=N)N)C(N)=O |
Synonyms
| (d-trp2,7,9)-substance p |
| arg-d-trp-lys-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2 |
| h-arg-d-trp-lys-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2 |
