Introduction：Basic information about CAS 101020-79-5|Ademetionine 1,4-butanedisulfonate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ademetionine 1,4-butanedisulfonate |
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| CAS Number | 101020-79-5 | Molecular Weight | 1451.621 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C42H74N12O28S8 | Melting Point | 125-135°C |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ademetionine 1,4-butanedisulfonate |
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| Synonym | More Synonyms |
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Ademetionine 1,4-butanedisulfonate BiologicalActivity
| Description | SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders[1][2][3][4]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| In Vivo | SAMe-1,4-Butanedisulfonate (30 和 60 mg/kg/天，肌肉注射) 增加实验性骨关节炎兔损伤软骨的厚度和细胞密度[2]。 SAMe-1,4-Butanedisulfonate (60 和 100 mg/kg/天，肌肉注射) 保护大鼠免受 d-半乳糖胺诱导的肝损伤[3]。 SAMe-1,4-Butanedisulfonate (10-200 mg/kg，腹腔注射) 对接受强迫游泳试验 (FST) 和悬尾试验 (TST) 的小鼠表现出抗抑郁样作用[4]。 Animal Model: Mice submitted to the forced swimming test (FST) and tail suspension test (TST)[4] Dosage: 10, 255, 50, 100, 200 mg/kg Administration: i.p. Result: Reduced the immobility time in the FST and reduced the total distance traveled. |
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| References | [1]. Delle Chiaie R, et al. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002 Nov;76(5):1172S-6S. [2]. Barceló HA, et al. Osteoartritis experimental y su evolución bajo tratamiento con S-adenosil-L-metionina (SAMe) [Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine]. Rev Clin Esp. 1990 Jun;187(2):74-8. Spanish. [3]. Stramentinoli G, et al. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem Pharmacol. 1978 May 15;27(10):1431-3. [4]. Sales AJ, et al. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochem Int. 2023 Jan;162:105442. |
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Chemical & Physical Properties
| Melting Point | 125-135°C |
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| Molecular Formula | C42H74N12O28S8 |
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| Molecular Weight | 1451.621 |
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| Exact Mass | 1450.250122 |
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| PSA | 798.02000 |
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| LogP | 3.14480 |
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| InChIKey | QWARKYOPJRNOOU-RLUFNZFXSA-N |
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| SMILES | C[S+](CCC(N)C(=O)O)CC1OC(n2cnc3c(N)ncnc32)C(O)C1O.C[S+](CCC(N)C(=O)O)CC1OC(n2cnc3c(N)ncnc32)C(O)C1O.O=S(=O)(O)CCCCS(=O)(=O)O.O=S(=O)(O)CCCCS(=O)(=O)O.O=S(=O)([O-])CCCCS(=O)(=O)[O-] |
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Safety Information
Synonyms
| S-Adenosylmethione-1,4-butanedisulfonate |
| Ademethionine 1,4-Butanedisulfonate |
| AdeMetionine 1,4-Butandisulphate |
| S-ADENOSYLMETHIONINE1,4-BUTANEDUSULFONATE |
| [(3S)-3-Amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl}methylsulfonium 1,4-butanedisulfonate - 1,4-butanedisulfonic acid (2:1:2) (non-preferred name) |
| s-adenosylmethionine 1,4-butanedisulfonate |
| S-Adenosyl-L-methionine 1,4-butanedisulfonate sodium salt |
