Introduction：Basic information about CAS 483-90-9|Toddalolactone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Toddalolactone |
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| CAS Number | 483-90-9 | Molecular Weight | 308.326 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 530.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H20O6 | Melting Point | / |
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| MSDS | / | Flash Point | 195.5±23.6 °C |
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Names
| Name | 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one |
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| Synonym | More Synonyms |
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Toddalolactone BiologicalActivity
| Description | Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>PAI-1Research Areas >>Cardiovascular Disease |
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| In Vitro | Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1]. |
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| References | [1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 530.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H20O6 |
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| Molecular Weight | 308.326 |
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| Flash Point | 195.5±23.6 °C |
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| Exact Mass | 308.125977 |
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| PSA | 89.13000 |
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| LogP | 0.88 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.569 |
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| InChIKey | GLWPLQBQHWYKRK-UHFFFAOYSA-N |
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| SMILES | COc1cc2oc(=O)ccc2c(OC)c1CC(O)C(C)(C)O |
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| Storage condition | 2-8C |
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Synonyms
| 2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy- |
| 6-[(2r)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2h-chromen-2-one |
| 6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-chromen-2-one |
| (+)-toddalolactone |
| Toddaline |
| Toddalolactone |
