CAS 50-57-7|[Lys8]-Vasopressin TFA
| Common Name | [Lys8]-Vasopressin TFA | ||
|---|---|---|---|
| CAS Number | 50-57-7 | Molecular Weight | 1056.218 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1610.4±65.0 °C at 760 mmHg |
| Molecular Formula | C46H65N13O12S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 927.7±34.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Lypressin |
|---|---|
| Synonym | More Synonyms |
[Lys8]-Vasopressin TFA BiologicalActivity
| Description | Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Sequence: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2(Disulfide bridge: Cys1-Cys6). |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>OthersPeptides |
| References | [1]. Gorbulev V et al. Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line. Eur J Biochem. 1993 Jul 1;215(1):1-7. [2]. Crankshaw D et al. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle.Eur J Pharmacol. 1989 Dec 7;173(2-3):183-8. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1610.4±65.0 °C at 760 mmHg |
| Molecular Formula | C46H65N13O12S2 |
| Molecular Weight | 1056.218 |
| Flash Point | 927.7±34.3 °C |
| Exact Mass | 1055.431763 |
| PSA | 476.15000 |
| LogP | -5.74 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.581 |
| InChIKey | BJFIDCADFRDPIO-DZCXQCEKSA-N |
| SMILES | NCCCCC(NC(=O)C1CCCN1C(=O)C1CSSCC(N)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(Cc2ccccc2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N1)C(=O)NCC(N)=O |
| Storage condition | −20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 5 iu/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 17,419,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraarterial
- DOSE :
- 0.25 iu/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 17,419,1968
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H332 |
| Precautionary Statements | P261 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YW8659000 |
Articles36
More Articles| Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure. PLoS ONE 8(1) , e52683, (2013) Only a limited proportion of patients needing pharmacological control of portal hypertension are hemodynamic responders to propranolol. Here we analyzed the effects of zolmitriptan on portal pressure ... | |
| Effects of terlipressin on microcirculation of small bowel mesentery in rats with endotoxic shock J. Surg. Res. 188(2) , 503-9, (2014) Background Septic shock is still related to unacceptably high morbidity and mortality. Microcirculatory alteration has been demonstrated to be one important reason associated with this evolution. Vaso... | |
| Terlipressin resolves ascites of cirrhotic rats through downregulation of aquaporin 2. J. Int. Med. Res. 40(5) , 1735-44, (2012) To investigate the presence of aquaporin (AQP) 1 and AQP2 in kidneys of cirrhotic rats with ascites, and to determine the effect of terlipressin on AQP1 and AQP2 levels and its therapeutic efficacy in... |
Synonyms
| EINECS 200-050-5 |
| syntopressin |
| postacton |
| Lysipressin Acetate |
| CYFQNCPKG-NH2 |
| LVP |
| [Lys8]-vasopressin |
| LYSPRESSIN |
| lypressin |
| 8-lysine-vasopressin |
| lysinepitressin |
| diapid |
| lysine-vasopressin |
| Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-lysyl- |
| L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysylglycinamide Cyclic (1®6)-Disulfide |
| (8-Lysine)vasopressin |
| 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-lysylglycinamide |
| Lysipressin |
| Lysine Vasopressin |
| Cys-Pro-Arg-Gly-NH2 |
| c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2 |
| CYS-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2(DISULFIDE BRIDGE:CYS1-CYS6) |
| Lypressin Acetate |
